eng Science and Education Publishing American Journal of Medical Case Reports 2374-216X 2020-09-25 8 12 498 502 10.12691/ajmcr-8-12-19 AJMCR202081219 article Filip Oleszak 1 Andrii Maryniak 1 Evan Botti 1 Christian Abrahim 2 Moro O. Salifu 2 Mary Youssef 2 Victoria L. Henglein 2 Samy I. McFarlane smcfarlane@downstate.edu 2 Department of Internal Medicine, State University of New York (SUNY): Downstate Health Science University, Brooklyn, New York, USA Division of Cardiology, Department of Internal Medicine, UMMS-Baystate Medical Center, Springfield Massachusetts, USA Coronavirus disease 2019 (COVID-19) has rapidly evolved into a global pandemic, with affecting to-date over 23 million people and causing over 800,000 deaths around the globe. The major pathogenetic mechanisms include inflammation, vasoconstriction and thrombogenesis. Infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) typically manifests as fever, cough, shortness of breath, and exhibits radiographic evidence of bilateral pneumonic infiltrates. Recent meta-analyses have shown that myocardial injury, including viral myocarditis, is prevalent among infected patients, especially in patients requiring ICU level care. Diagnosis of viral myocarditis is multifactorial and involves detection of elevated cardiac biomarkers and echocardiographic evidence of cardiomyopathy, in the absence of diseased coronary arteries. Endomyocardial biopsy with histopathologic examination provides definitive confirmation. We present a case of a previously healthy 52-year-old male who presented clinically with suspected myocarditis with new-onset dilated cardiomyopathy (DCM) and systolic dysfunction as a sequela of infection with SARS-CoV-2. In this report we highlight the clinical presentation of echocardiographic findings and proposed pathogenetic mechanisms of myocarditis associated with COVID-19 which has a varied presentation, ranging from clinically silent to life-threatening arrhythmias with hemodynamic compromise. http://pubs.sciepub.com/ajmcr/8/12/19/ajmcr-8-12-19.pdf SARS-CoV-2 Myocarditis COVID-19 Cardiac manifestations Pathogenesis