eng Science and Education Publishing American Journal of Medical Case Reports 2374-216X 2020-09-23 8 12 496 497 10.12691/ajmcr-8-12-18 AJMCR202081218 article Zainab Abbasi drzainab.abbasi@gmail.com 1 Muhammad Faizan Ahmed 2 Sejal Neel 2 Amro Elshereye 2 Ifeanyichukwu David Onukogu 2 Internal Medicine, Liaquat University of Medical and Health Sciences, Jamshoro, 76090 Pakistan Internal Medicine, Brookdale Hospital Medical Center, Brooklyn, NY, 11212, USA Acute Ischemic Hepatitis in sickle cell disease could lead to acute hepatic failure. The term Sickle Cell Hepatopathy encompasses a wide range of hepatic manifestations that occur due to this disease itself or secondary to treatment. Although our patient had a homozygous inheritance for the sickle cell gene but never experienced any hepatic complications of the disease. Our patient experienced an acute hepatic sequestration crisis which otherwise usually occurs in the spleen. This case signifies the importance of early evaluation and management of hepatic involvement in sickle cell disease to prevent overt hepatic failure. http://pubs.sciepub.com/ajmcr/8/12/18/ajmcr-8-12-18.pdf sickle cell disease hepatic sequestration crisis acute ischemic hepatitis acute abdominal pain exchange transfusion