Dear Label_Name,

Greetings! I hope you are well.

I am writing on behalf of an international publishing house, Science and Education Publishing, USA (http://www.sciepub.com).

Science and Education Publishing (SciEP) is a multidisciplinary open access publisher of Journals covering the fields of Science, Technology and Medicine. All SciEP publications are subject to high-quality peer review, editorial and production processes and are freely available online.

Welcome to the April, 2013 edition of SciEP newsletter, providing monthly summaries of articles on science & education related topics of interest to scientist and professionals. The mission of our journals is to provide an open access forum for publishing new findings on issues pertinent to scientific and academic field. We also invite you to submit original research papers, review articles, short reports, or case studies are considered for publication in our Multidisciplinary Journals.

American Journal of Public Health Research
DOI: 10.12691/ajphr-1-1-3

The Implementation of a Tele-Homecare System with Service Oriented Architecture and HL7 Message Transmission Standard
Ching-Sung Wang

American Journal of Medical and Biological Research
DOI: 10.12691/ajmbr-1-1-2

The Influence of Ethanol on Pyruvate Kinases Activity in Vivo, in Vitro, in Silico
Lelevich Sergey Vladimirovich, Khrustalev Vladislav Victorovich, Barkovsky Eugene Victorovich, Shedogubova Tatyana Aleksandrovna

American Journal of Medical Sciences and Medicine
DOI: 10.12691/ajmsm-1-1-1

Clinical and Histological Features in Wegener Granulomatosis
Li Cavoli Gioacchino, Passantino Rita, Bono Luisa, Tortorici Calogera, Ferrantelli Angelo, Giammarresi Carlo, Rotolo Ugo

American Journal of Infectious Diseases and Microbiology
DOI: 10.12691/ajidm-1-1-2

The Curse of Lymphatic Filariasis: Would the Continual Use of Diethylcarbamazine Eliminate this Scourge in Papua New Guinea?
Anne Lanham, Lillian Mwanri

We have released issues of some journals on February 2013.
American Journal of Public Health Research
American Journal of Medical Sciences and Medicine
American Journal of Medical and Biological Research
American Journal of Pharmacological Sciences
American Journal of Clinical Medicine Research
American Journal of Nursing Research
American Journal of Cancer Prevention
American Journal of Medicine Studies
American Journal of Infectious Diseases and Microbiology
American Journal of Cardiovascular Disease Research
American Journal of Biomedical Research
American Journal of Mechanical Engineering
American Journal of Microbiological Research
Journal of Preventive Medicine
American Journal of Food and Nutrition
American Journal of Hypertension Research
American Journal of Sports Science and Medicine
Journal of Cancer Research and Treatment
American Journal of Zoological Research
Journal of Biomedical Engineering and Technology
American Journal of Microbiological Research
Biomedical Science and Engineering

We are pleased to announce that submissions are now being accepted for peer review for all the journals across all our subject areas in SciEP.

Please submit your manuscript via our online submission system:
http://www.sciepub.com/author/signin

To unsubscribe from our mailing list, please click on the following link: unsubscribe

I am looking forward to hearing from you.

Kind regards,

David Rain
Email:join@sciepub.com
Science and Education Publishing (http://www.sciepub.com)

A Case of Scrub Typhus with Multiple Eschars and New-Onset Atrial Fibrillation

Yoshimoto Takaaki*, Yoshimoto Taiji

Hitachiota City Kegano Clinic, Hitachiota City, Ibaraki, Japan

Abstract: We report a case of scrub typhus with multiple eschars and acute myocarditis with a new onset atrial fibrillation in a 53 year-old man. Eschar and cardiovascular complications of scrub typhus were discussed.

Keywords: eschar, myocarditis, atrial fibrillation

Received July 28, 2020; Revised August 30, 2020; Accepted September 08, 2020

Citation: Yoshimoto Takaaki, Yoshimoto Taiji, A Case of Scrub Typhus with Multiple Eschars and New-Onset Atrial Fibrillation. American Journal of Medical Case Reports, 8 (12). 474-477. January 2020. doi:10.12691/ajmcr-8-12-11

1. Introduction

Scrub typhus, also called tsutsugamushi disease in Japan, is an acute febrile disease caused by orientia tsutsugamushi, an obligate intracellular gram-negattive bacteria. Human are infected accidently by the bite of the larva (chigger) harboring this bacteria. It is a serious health problem especially in the endemic regions known as tsutsugamushi triangle.

The World Health Organization (WHO) in 1999 stated that scrub typhus is probably one of the most underdiagnosed and an underreported disease that often required hospitalization.

Fever, skin eruption and eschar are three major clinical symptoms of scrub typhus. The percentage of eschar varies among areas of endemicity, races, and the researchers (reporters), high in individuals of Japanese and Korean ancestries, low in Southeast Asians with dark skin. The number of eschar is usually one, but may be more than one in very rare cases.

Serious cardiovascular complications of scrub typhus were reported in the second-third week of the clinical course, as a result of delayed or untreated cases (mostly, in the pre-antibiotic era) complicated with fatal disseminated multiple organ failure.

2. Case Presentation

A 53 year-old male with a medical history of well controlled hypertension presented with chief complaint of a fever and malaise for three days. Physical examination revealed that his body temperature was 38.20C (axillary), blood pressure, 72/48mmHg. irregular heart beat. ECG showed atrial fibrillation with rapid heart beat (Figure 1, Figure 2). Morbiliform skin eruption over his chest and proximal aspects of the extremities were observed (Figure 3). Typical eschars at his right lower extremitity and left leg were found via a thorough skin check (Figure 4, Figure 5). Routine blood tests showed a high white blood cell count (WBC), 11700/μL 4% atypical lymphocytes, elevated C-reactive Protein 6,3mg/dl, impaired liver function test; aspartate transaminase (AST), 54/μL alanine transaminase (ALT). 50/μL gammaglutamyl transpeptidase (γ-GTP) 61 /μL, lactate dehydrogenase (LDH) 537/μL creatine and platelet count were within normal range, Creatine-Kinase-MB (CK-MB) was 8.58ng/ml (normal <2.2 ng/ml), cardiac troponin T was 0.033 ng/ml (normal <0.014 ng/ml), and BNP was 178 pg/ml (normal<l18.4 pg/ml).

Figure. 1. EKG taken on the day of his first visit showed atrial fibrillation with rapid ventricular rate (V1-V6).

Figure 2. Atrial fibrillation with rapid ventricular response 141/min (limb leads)

Figure 3. Morbiliform skin rash over chest and proximal parts of extrimities

Figure 4. Multiple eschars over his right lower extremity with a typical one at medial aspect of knee joint

Figure 5. A typical eschar at left leg of the patient

Echocardiography showed absence of kinetic A wave in left ventricular inflow. Pleural or pericardial effusion were not observed. Global hypokinesia with a left ventricular ejection fraction 48% was detected.

Orientia tsutsugamushi infection (Kawasaki serotype) was proved by Nested Polymerase Reaction (PCR) with patient’s eschar before antibiotic therapy. Immunofluorescent Antibody (IFA) performed ten days after his first visit showed a highest titer of Kawasaki serotype among six strains of scrub typhus (Table 1).

Table 1. Serological data of Immunofluorescent Antiboby (IFA)

Intravenous infusion of 500ml normal saline with one ampule digoxin(0.25 mg ) was initiated immediately for hemodynamic support. Minocyline 200mg/day orally for one week was prescribed. His fever was subsided within 24 hours after the initiation of antibiotic treatment. In the morning of the next day, his blood pressure was 126/70 mmHg, ECG was reverted to ordinary sinus rhythm, 81/min (Figure 6, Figure 7). Recurrence of atrial fibrillation did not occur at follow-up visits. Dosage of his hypertension medications (calcium antagonist, angiotensio II receptor blocker) were cautiously adjusted.

Figure 6. ECG taken in the moring of day 2. showed ordinary sinus rhythm (V1-V6) with a regular heart beat 81/min

Figure 7. ECG (limb leads) taken in the moring of day 2, showed ordinary sinus rhythm with a regular heart beat 81/min

3. Discussion

Scrub typhus (ST) and Japanese Spotted Fever (JSF) are two main rickettsial infectious diseases in Japan and were classified as Category IV infectious diseases designated by the government ordinance in 1999.

Fever, skin eruption and eschar are three main clinical symptoms of scrub typhus. Eschar, the location where the chigger feeds, pathogomonic of scrub typhus can occur at any part of the body, including head, ear cannals, axillary fossa, umbilicus, genital and anal areas. Eschar is usually painless and not pruritic. In classical type of scrub typhus, patients may remember a pain during being stabbed by akamushi larva. The percentage of skin eruption and eschar vary among races, areas of endemicity and serotypes of ST, high in individuals of Japanese and Korean ancestries and low in Southest Asians who contracted the disease. Thorough check of skin, including genital areas in females, increased the percentage of eschar from 82.6% to 100% of scrub typhus cases, was reported by a Japanese researcher Dr. Araiyorou. [1]. We experienced some cases of scrub typhus, the eschars were found when hypernemia of patients’ skin were resolved and the rashes faded.

In scrub typhus, dissemination of the bacteria via vasculitis and perivasculitis may involve lung, heart, liver, spleen, kidney, pancreas and central nervous system. Cardiovascular complications of scrub typhus is rare and is usually subclinical. Cardiomyocardial lesions in untreated patients were more frequent in the pre-antibiotic era, usually during the second to third week of illness. The use of effective antibiotics has reduced the complications of scrub typhus. ECG abnormalities were usually nonspecific; sinus tachycardia, non-specific ST-T changes, T wave abnormalitity, atrial and ventricular premature beats, AV block. prolongation of QTc interval. However, patients of scrub typhus with paroxysmal atrial fibrillation and torades de pointes need special attention [2]. In South Korea, a total of 233473 patients diagnosed with scrub typhus from 2006 to 2016, 2402 cases (1%) case were reported to have new-onset atrial fibrillation. New-onset atrial fibrillation was significantly associated with three month mortality rate and concurrent cardiac adverse outcomes, acute heart failure (AHF) and ischemic heart disease (IHD) [3].

Antibiotics such as Tetracycline, doxycycline, minocycline, azithromycin, rifampicin are effective for treatment of scrub typhus. Minocycline 200mg/D for 7 days is the standard treatment of scrub typhus for adult in Japan. Chloramphenicol is also effective (often used, in Southest Asia). Rifampicin is effective in areas where doxycycline resistance is present. Differrent schemes (treatment options) have been evaluated by many researchers. For instance, doxycycline, 100mg twice daily for 7 days, orally or intravenously, chloramphenicol 500mg, four times daily, azithromycin 500mg/D for 3-5 days, rifampicin 600-900mg daily for 7 days [4].

Azithromycine, is classified in category B by the US Food and Drug Administration (US FDA) Pregnanancy Category and is the suggested alternative drug in these patients and young children under 8 years-old [5]. Routine ECG, serum level of electrolytes, liver and renal function should be carefully checked in the patients of ST treated with azithromycin that prolong QT intervals.

Pathophysiology of atrial fibrillation is not yet completely understood. Inflammatory biomarkers such as cytocines, IL-I beta, IL-6, IL-8, IL-10, TNF-alpha (tumor necrosis factor), Interferon ( IFN- gamma), transforming growth factor (TGF-betta) and high-sensitivity C-reactive protein (hs-CRP) has received increasing attention recently. High sensitivity C-reactive protein and interleukins (IL-1, IL-2) have been associated with the occurrence of AF and its prognosis. Inflammation and oxidative stress may be the key mechanism underling the initiation and maintenance of atrial fibrillation. Atrial electrical remolding begin within a few hours after the onset of atrial fibrillation resulting in decreased atrial refractory period conduction heterogeneity, abnormal calcium ionic handling, increased P wave dispersion and atrial ectopy [6].

Acute myocarditis in scrub typhus can present with a wide range of clinical manifestations, from nonspecific symptoms, such as fever, palpitation, malaise, dyspnea, to cardiac arrythmia syndrome, cardiogenic shock or sudden cardiac death. Endocardial biopsy are essential in confirming the diagnosis of myocarditis. Yet, some limitations restrict its application. The inflammation may be focal and this technique is invasive in hemodynamically unstable patients. Cardiac magnetic resonance (Cardiac MRI) enables clinicians to access cardiac function indirectly, and also provide assistance in directing myocardial biopsy to appropriate locations [7].

Three types of troponins exists, troponin T (cTnT), troponin I(cTnI) and troponin C(cTnC). Each subunit has a unique function; cTnT binds the troponin components to tropomyosin, cTn I inhibits the interaction of myosin with actin, and cTnC contains the binding sites for Ca2+ that helps initiating contraction. Troponin T is released into the blood stream when damage to heart muscle occur [8].

Scrub typhus with multiple eschars complicated with acute myocarditis with a new onset atrial fibrillation on the third day of illness highlights this interesting case. Scrub typhus with such complication is potentially fatal. Early diagnosis, prompt effective antibiotics and haemodynamic support resulted in good cardiac recovery in this patient.

Follow-up echocardiography of the patient revealed no clinically significant stenosis or regurgitation of heart valves (aortic, mitral, tricuspid and pulmonary). Respiratory collapse of inferior vena was complete. Left ventricular inflow pattern; E/A, 60.5/58.4cm/s, deceleratiom time, 170msec. Left ventricular ejection fraction was 63%. Mitral annulus velocity on tissue Doppler; e/a’, 14.7/12 cm/s and E/e’, 60.5/14.7 cm/s.

WBC count, liver function and cardiac biomarkers of the patient were within normal limit at follow- up visits.

Cover Letter

This manuscript (A Case of Scrub Typhus with Multiple Eschars and New-onset Atrial Fibrillation) is original and has not already been published elsewhere.

Competing Interest

The authors declare that there have no competing interest exist.

References

[1]   | Araiyorou. Winter Scrub Typhus of Izu Shichito Islands, Japan. Kansenshougakuzasshi 280-302 1953. (in Japanese).
[2]   | kim JH, Kim SK, Chung MH, et al. Torsades de Pointes by Azithromycin in Scrub Typhus and Review on Cardiac Manifstations of Scrub typhus. Infect Chemother. Jan-Feb; 40(1): 58-62. 2008.
[3]   | Jang SY, Kang KW, Kim JH, et al. New-onset atrial fibrillation predicting complicating cardiac adverse outcome in scrub typhus infection Clin Cardiol. Dec; 42(12): 1210-1221. 2019.
[4]   | Peter JV, Prakash AN. Varghese GM Serere scrub typhus infection: Clinical features, diagnostic challenges and management. World J Crit Care Med 4; 4(3): 244-250, 2015.
[5]   | Kim YS, Lee Hj, Chang M, et al. Scrub typhus during pregnancy and its treatments: a case series and review of the lecture. Am J Trop Med Hyg 75: 935-9. 2006.
[6]   | Boos CJ. Infection and atrial fibrillation: inflammation begets AF. Eur. Heart J; 41; 1120-1122, 2020.
[7]   | Ki YJ, Kim DM, Yoon NR et al. A case report of scrub typhus complicated with myocarditis and rhabdomyocitis. BMC Infectious Dseases 18: 551. 2018.
[8]   | Braunwald's Heart Disease. Elsevier Saunders. 2015. P.433.