eng Science and Education Publishing American Journal of Medical Case Reports 2374-216X 2020-09-03 8 12 471 473 10.12691/ajmcr-8-12-10 AJMCR202081210 article Ankit Dubey Ankit.dubey@phh.ms 1 Jaspreet Dhanjal 1 Chukwuemeka A. Umeh 1 Department of Internal Medicine, Hemet Valley Medical Center, Hemet, California, USA While the prevalence of syphilis had seen a significant decrease in the post-antibiotic era, it can still present in immunocompromised patients. While it is rare for immunocompetent patients to present with advanced stages of Syphilis, prompt recognition and diagnosis is imperative to prevent serious complications. We present the case of a 52 year old immunocompetent female who was diagnosed with syphilis 30 years ago who presented with vague symptoms including a rash, blurred vision, and headache and was diagnosed with early neurosyphilis. http://pubs.sciepub.com/ajmcr/8/12/10/ajmcr-8-12-10.pdf neurosyphillis immunocompetent