Dear Label_Name,

Greetings! I hope you are well.

I am writing on behalf of an international publishing house, Science and Education Publishing, USA (http://www.sciepub.com).

Science and Education Publishing (SciEP) is a multidisciplinary open access publisher of Journals covering the fields of Science, Technology and Medicine. All SciEP publications are subject to high-quality peer review, editorial and production processes and are freely available online.

Welcome to the April, 2013 edition of SciEP newsletter, providing monthly summaries of articles on science & education related topics of interest to scientist and professionals. The mission of our journals is to provide an open access forum for publishing new findings on issues pertinent to scientific and academic field. We also invite you to submit original research papers, review articles, short reports, or case studies are considered for publication in our Multidisciplinary Journals.

American Journal of Public Health Research
DOI: 10.12691/ajphr-1-1-3

The Implementation of a Tele-Homecare System with Service Oriented Architecture and HL7 Message Transmission Standard
Ching-Sung Wang

American Journal of Medical and Biological Research
DOI: 10.12691/ajmbr-1-1-2

The Influence of Ethanol on Pyruvate Kinases Activity in Vivo, in Vitro, in Silico
Lelevich Sergey Vladimirovich, Khrustalev Vladislav Victorovich, Barkovsky Eugene Victorovich, Shedogubova Tatyana Aleksandrovna

American Journal of Medical Sciences and Medicine
DOI: 10.12691/ajmsm-1-1-1

Clinical and Histological Features in Wegener Granulomatosis
Li Cavoli Gioacchino, Passantino Rita, Bono Luisa, Tortorici Calogera, Ferrantelli Angelo, Giammarresi Carlo, Rotolo Ugo

American Journal of Infectious Diseases and Microbiology
DOI: 10.12691/ajidm-1-1-2

The Curse of Lymphatic Filariasis: Would the Continual Use of Diethylcarbamazine Eliminate this Scourge in Papua New Guinea?
Anne Lanham, Lillian Mwanri

We have released issues of some journals on February 2013.
American Journal of Public Health Research
American Journal of Medical Sciences and Medicine
American Journal of Medical and Biological Research
American Journal of Pharmacological Sciences
American Journal of Clinical Medicine Research
American Journal of Nursing Research
American Journal of Cancer Prevention
American Journal of Medicine Studies
American Journal of Infectious Diseases and Microbiology
American Journal of Cardiovascular Disease Research
American Journal of Biomedical Research
American Journal of Mechanical Engineering
American Journal of Microbiological Research
Journal of Preventive Medicine
American Journal of Food and Nutrition
American Journal of Hypertension Research
American Journal of Sports Science and Medicine
Journal of Cancer Research and Treatment
American Journal of Zoological Research
Journal of Biomedical Engineering and Technology
American Journal of Microbiological Research
Biomedical Science and Engineering

We are pleased to announce that submissions are now being accepted for peer review for all the journals across all our subject areas in SciEP.

Please submit your manuscript via our online submission system:
http://www.sciepub.com/author/signin

To unsubscribe from our mailing list, please click on the following link: unsubscribe

I am looking forward to hearing from you.

Kind regards,

David Rain
Email:join@sciepub.com
Science and Education Publishing (http://www.sciepub.com)

Less is More: Managing Non-Sustained Ventricular Tachycardia in a Patient with SARS-CoV2 Infection

Paul Madaj, Lu Chen, Yuvraj Singh Choudhury, Robert M Donnino, Cristina A Mitre*

Division of Cardiology, Department of Medicine, Veteran Affairs New York Harbor Healthcare System, Brooklyn Campus, Brooklyn, NY 11209

Abstract: The novel coronavirus disease 2019 (COVID-19) has changed our lives and reshaped our approach to management of various cardiovascular diseases. Ventricular tachycardia (VT) is a potentially life-threatening arrhythmia, most often seen in patients with structural heart disease. If underlying ischemia is suspected, coronary angiography is usually performed on a non-elective basis. In patients with active COVID-19, additional risks of the procedure must be considered for patients and for operators. This case illustrates the management of suspected ischemic VT and discusses the dilemma physicians must face in the ongoing COVID-19 pandemic.

Keywords: ventricular tachycardia, novel coronavirus, COVID, coronary artery disease, ischemic injury

Received July 01, 2020; Revised July 13, 2020; Accepted July 22, 2020

Citation: Paul Madaj, Lu Chen, Yuvraj Singh Choudhury, Robert M Donnino, Cristina A Mitre, Less is More: Managing Non-Sustained Ventricular Tachycardia in a Patient with SARS-CoV2 Infection. American Journal of Medical Case Reports, 8 (11). 389-393. January 2020. doi:10.12691/ajmcr-8-11-3

1. Introduction

Since the isolation of severe acute respiratory syndrome Coronavirus 2 (SARS-CoV-2) in January of 2020, the novel coronavirus disease 2019 (COVID-19) has been sweeping through the world, changing the lifestyle of everyone. A variety of cardiovascular manifestations in COVID-19 were reported, including but not limited to arrhythmias, myocardial infarction, myocarditis, peripheral and central thrombosis [1,2]. Furthermore, the presence of cardiovascular complications was described as an independent risk factor for increased critical illness as well as mortality in COVID-19 patients [3,4].

Arrhythmia has been described to be associated with both the treatment and the primary disease process of COVID-19 [5]. In particular, ventricular tachycardia (VT) carries significant consequences of morbidity and mortality as it can lead to hemodynamic compromise and sudden cardiac death. There are multiple primary cardiac etiologies responsible for VT, such as ischemic disease, non-ischemic cardiomyopathy, myocarditis, congenital heart disease, and scars from prior cardiac surgeries [6].

Without an effective treatment to date, COVID-19 forced us to reconsider our therapeutic approaches. For example, in patients with suspected ST elevation myocardial infarction, some hospitals have taken precautions to ensure accurate diagnosis with bedside echocardiography [7]. Others have recommended thrombolytic therapy as initial management [8]. Regardless, thorough decontamination after planned intervention has been suggested [9,10]. Elective intervention for coronary artery disease (CAD) have been deferred to downsize case volume in laboratories and reduce exposure to SARS-CoV2 for both patients and health care workers (HCW) [10]. Urgent procedures were left to physicians’ discretion. Optimal timing of non-elective procedures is determined on a case-by-case basis. This case describes the management challenges we faced for a patient with VT due to suspected ischemic injury during the ongoing COVID-19 pandemic.

2. Case

A 69-year old male presented to the emergency department with worsening shortness of breath, non-productive cough, and bilateral lower extremity edema for seven days. He had a past medical history of non-obstructive CAD, atrial fibrillation, remote history of ventricular septal defect (VSD) repair in his youth. He denies history of syncope, dizziness or exertional chest pain. On presentation, patient was hemodynamically stable, but had tachypnea at 20 breaths per minute although maintaining adequate oxygen saturation of 97% on room air. His physical exam revealed irregularly irregular heart rhythm with diffuse crackles on bilateral lung bases and +2 pitting edema in both of lower extremities. His outpatient medications included metoprolol, furosemide, and losartan. Laboratory studies were significant for positive SARS-CoV2 antigen and mildly elevated troponin-I and brain natriuretic peptide (BNP). The other laboratory studies were otherwise normal and detailed in Table 1. Chest radiography demonstrated mild bilateral infiltrates along with cardiomegaly. Electrocardiogram (EKG) showed atrial fibrillation with right bundle branch block, without prolongation of QT interval or ischemic changes (Figure 1a). Using the Hodges formula, QT interval was calculated at 400 milliseconds (ms), and a corrected QT (QTc) interval of 467 ms. He was admitted to telemetry floor for respiratory insufficiency in the setting of COVID-19 pneumonia with acute heart failure. Patient received his home medication, except diuretic was switched to intravenous (IV) treatment, and he was started on hydroxychloroquine with azithromycin following initial loading dose.

Overnight on hospital day 2, patient had a run of monomorphic ventricular tachycardia (Figure 1b) lasting 20 seconds. He was sleeping during this episode. He was free of chest pain and denied any symptoms. The patient was evaluated and accepted to our coronary care unit (CCU). He was started on oral loading dose of amiodarone while on telemetry, as CCU transfer was not immediately possible.

Urgent laboratory studies showed no significant abnormalities in his electrolytes. An urgent echocardiogram was obtained and revealed a newly reduced left ventricle ejection fraction (LVEF) of 40%, with new apical and septal akinesis. His right atrium and right ventricle size were severely dilated, however unchanged compared to prior echocardiogram done ten months ago (Figure 2a-c). His right ventricular systolic pressure was unchanged as well, at approximately 35 mmHg. Patient was then transferred to the CCU for further care. EKG obtained at this time did not demonstrate changes in his ST segment, but QT interval was prolonged (QT 465ms and QTc 509ms, Figure 1c). Azithromycin and hydroxychloroquine were held and only oral amiodarone was continued.

Table 1. Laboratory studies of patient during his hospitalization

Figure 1a. Electrocardiogram on admission to our hospital

Figure 1b. Telemetry tracing showing extended non-sustain ventricular tachycardia

Figure 1c. Electrocardiogram on hospital day #3

Figure 2. Echocardiogram showing distended inferior vena cava with severely dilated right ventricle and right atrium

Patient continued to improve with IV diuretic. Very short runs of VT and frequent ventricular premature contractions were still seen, but no sustained ventricular arrhythmia was noted on telemetry tracing. In consultation with interventional cardiology team, decision was made to defer ischemic evaluation until after COVID-19 pandemic on outpatient basis. Patient was discharged to home for self-isolation with telephone follow-ups

3. Discussion

Our case describes an arrhythmia that is commonly encountered by consulting cardiology services. Given its potential to cause significant hemodynamic instability, progression to ventricular fibrillation, and death, VT is especially concerning in patients with structural heart disease [6]. In a patient with newly identified reduced left ventricular ejection fraction (LVEF) and regional wall motion abnormality (RWMA) on echocardiography, ischemic injury becomes a significant concern. With the complexity of this patient’s cardiac history and active COVID-19 infection, additional considerations include acute myocarditis, side effect of medications, and scar burden associated with prior VSD repair.

In cases of uncertainty, both echocardiography and cardiac magnetic resonance imaging (cMRI) are powerful diagnostic tools to determine the etiology of VT. In our patient with reduced LVEF and new RWMA on bedside echocardiography, ischemic injury remains the most likely cause. Without additional clinical symptoms, electrocardiographic signs of coronary artery disease, and abnormal cardiac markers for ischemia, consideration for further diagnostic study is reasonable prior to coronary angiography in order to minimize HCW exposure in COVID-19. cMRI requires patient transportation and thorough decontamination compared to more mobile echocardiography. However, cMRI can better pinpoint inflammatory and fibrotic patterns to differentiate ischemic injury from myocarditis, infiltrative disease and surgical scar from prior VSD repair [11]. The non-invasive nature and relatively minimal personnel requirement make both studies attractive preliminary evaluations, and in the case of cMRI, a possible alternative to coronary angiography. Optimal timing of echocardiography and cMRI in such cases during COVID-19 pandemic is individualized and could benefit from larger scaled investigation. Computerized tomography coronary angiogram (CTA) is another diagnostic option. However, CTA is most powerful at ruling out severe CAD in low and intermediate risk patients and less effective in our patient with a higher suspicion of disease and known non-obstructive CAD. Exposure to radiation and ionized contrast should be considered as well, especially in light of frequent renal complications in patients with COVID-19 [12].

Under normal circumstances, the obvious next step for ischemic evaluation in patients with VT and newly reduced LVEF with RWMA would be coronary angiography, usually prior to discharge from the hospital. During COVID-19 pandemic, increased risk of invasive procedures for transmission of SARS-CoV-2 should be taken into consideration. Additional personnel and personal protective equipment requirements should be contemplated. Catherization laboratories are generally kept under positive pressure to minimize potential contamination, while negative pressure rooms are generally recommended for patients with potential airborne diseases, such as COVID-19 [13]. Increased risk of exposure to both interventional cardiologists and supporting team members should be balanced with the necessity and clinical benefit of planned procedure. Further investigations to explore the optimal timing and necessity of coronary catherization in asymptomatic patients would be beneficial.

4. Conclusion

COVID-19 pandemic has changed the landscape of healthcare community in many ways. This crisis has accelerated the dissemination of clinical knowledge but also had us question established clinical practices. Definition and timing of urgent and essential procedures are being challenged. For the individual patients and health care providers, perhaps, less is more during the time of this pandemic.

Acknowledgements

Authors would like to acknowledge the frontline health care workers in the New York Harbor VA system for their dedication in the care of our veterans and civilians in this time of crisis.

Statement of Ethics

The current study was exempted from IRB review.

Disclosure Statement

The authors have no conflicts of interest to declare.

Statement of Completing Interests

The authors report no external funding source for this study

References

[1]   | Long B, Brady WJ, Koyfman A, Gottlieb M. Cardiovascular complications in COVID-19. Am J Emerg Med. 2020 Apr.
[2]   | Chen L, Upadhya G, Guo US, Belligund P, Lee DK, Shalom I, et al. Novel Coronavirus-Induced Right Ventricular Failure and Point of Care Echocardiography: A Case Report. Cardiology. 2020 May; 1-6.
[3]   | Guo T, Fan Y, Chen M, Wu X, Zhang L, He T, et al. Cardiovascular Implications of Fatal Outcomes of Patients With Coronavirus Disease 2019 (COVID-19). JAMA Cardiol. 2020 Mar.
[4]   | Chen C, Chen C, Yan JT, Zhou N, Zhao JP, Wang DW. [Analysis of myocardial injury in patients with COVID-19 and association between concomitant cardiovascular diseases and severity of COVID-19]. Zhonghua Xin Xue Guan Bing Za Zhi. 2020 Mar; 48(0): E008.

[5]  
Lakkireddy DR, Chung MK, Gopinathannair R, Patton KK, Gluckman TJ, Turagam M, et al. Guidance for Cardiac Electrophysiology During the Coronavirus (COVID-19) Pandemic from the Heart Rhythm Society COVID-19 Task Force; Electrophysiology Section of the American College of Cardiology; and the Electrocardiography and Arrhythmias Committee of the Council on Clinical Cardiology, American Heart Association. Heart Rhythm. 2020 Apr.

[6]   | Shivkumar K. Catheter Ablation of Ventricular Arrhythmias. N Engl J Med. 2019 18; 380(16): 1555-64.
[7]   | Ranard LS, Ahmad Y, Masoumi A, Chuich T, Romney M-LS, Gavin N, et al. Clinical Pathway for Management of Suspected or Positive Novel Coronavirus-19 Patients With ST-Segment Elevation Myocardial Infarction. Crit Pathw Cardiol. 2020; 19(2): 49-54.
[8]   | Jing Z-C, Zhu H-D, Yan X-W, Chai W-Z, Zhang S. Recommendations from the Peking Union Medical College Hospital for the management of acute myocardial infarction during the COVID-19 outbreak. Eur Heart J. 2020 May; 41(19): 1791-4.

[9]  
The American Heart Association’s Get With The Guidelines-Coronary Artery Disease Advisory Work Group And Mission Lifeline Program null, The American Heart Association’s Council On Clinical Cardiology null, The American Heart Association’s Council On Clinical Cardiology’s Committee On Acute Cardiac Care And General Cardiology Committee null, The American Heart Association’s Council On Clinical Cardiology’s Committee Interventional Cardiovascular Care Committee null. Temporary Emergency Guidance to STEMI Systems of Care During the COVID-19 Pandemic: AHA’s Mission: Lifeline. Circulation. 2020 May.

[10]   | Welt FGP, Shah PB, Aronow HD, Bortnick AE, Henry TD, Sherwood MW, et al. Catheterization Laboratory Considerations During the Coronavirus (COVID-19) Pandemic: From the ACC’s Interventional Council and SCAI. J Am Coll Cardiol. 2020 May; 75(18): 2372-5.
[11]   | Saeed M, Liu H, Liang C-H, Wilson MW. Magnetic resonance imaging for characterizing myocardial diseases. Int J Cardiovasc Imaging. 2017 Sep; 33(9): 1395-414.
[12]   | Pei G, Zhang Z, Peng J, Liu L, Zhang C, Yu C, et al. Renal Involvement and Early Prognosis in Patients with COVID-19 Pneumonia. J Am Soc Nephrol JASN. 2020 Apr.

[13]  
Szerlip M, Anwaruddin S, Aronow HD, Cohen MG, Daniels MJ, Dehghani P, et al. Considerations for cardiac catheterization laboratory procedures during the COVID-19 pandemic perspectives from the Society for Cardiovascular Angiography and Interventions Emerging Leader Mentorship (SCAI ELM) Members and Graduates. Catheter Cardiovasc Interv Off J Soc Card Angiogr Interv. 2020 Mar..