eng Science and Education Publishing American Journal of Medical Case Reports 2374-216X 2019-07-09 7 8 160 161 10.12691/ajmcr-7-8-2 AJMCR2019782 article Munawwar Hussain mhussain@conemaugh.org 1 Ahmed Khalil 1 Nazish Malik 1 Department of Internal Medicine, Conemaugh Health System, Johnstown PA 15905, USA Primary small cell carcinoma of urinary bladder is rare and aggressive neuroendocrine tumor. It is part of neuroendocrine tumor family that affects respiratory system, gastro intestinal tract and genitourinary system of male and female. We report a case of primary small cell carcinoma of urinary bladder treated with chemotherapy. Patient is 81 year old male who presented to emergency department with recurrent urinary retention associated with hematuria. Patient had cystoscopy and was diagnosed with small cell carcinoma of urinary bladder with no distant metastasis. Patient was treated with chemotherapy. Patient died with septic shock due to clostridium difficile colitis. http://pubs.sciepub.com/ajmcr/7/8/2/ajmcr-7-8-2.pdf small cell cystoscopy clostridium difficile colitis