eng Science and Education Publishing American Journal of Medical Case Reports 2374-216X 2019-05-21 7 5 90 93 10.12691/ajmcr-7-5-4 AJMCR2019754 article Salem Bouomrani salembouomrani@yahoo.fr 1 2 Karama Regaïeg 3 Nesrine Belgacem 3 Mouna Guermazi 3 3 Sami Krimi 3 Abdelfatteh Zakhama 4 Department of Internal Medicine, Military Hospital of Gabes, Gabes 6000, Tunisia Department of Forensic Medicine, Gabes Regional Hospital, Gabes 6000, Tunisia Department of Pathology, Fattouma Bourguiba Hospital, Monastir 5000, Tunisia Granulomatosis with polyangiitis (GPA), formerly known as Wegener's disease, is a rare necrotizing and granulomatous systemic vasculitis of small vessels. Cardiac involvement in GPA is unusual and the heart is part of the so-called "atypical" locations of this vasculitis. This complication is often little-known and overlooked by clinicians despite its severity and high mortality. Symptomatic acute myocardial infarction is an exceptional presentation of cardiac involvement associated to GPA. We report an original observation of fatal cardiac damage revealing GPA in a 50-year-old Tunisian man with no pathological medical history. The diagnosis was made on post-mortem examination. http://pubs.sciepub.com/ajmcr/7/5/4/ajmcr-7-5-4.pdf granulomatosis with polyangiitis Wegener’s disease cardiac involvement myocardial infarction sudden death vasculitis