eng Science and Education Publishing American Journal of Medical Case Reports 2374-216X 2019-02-24 7 2 27 28 10.12691/ajmcr-7-2-4 AJMCR2019724 article Tanveer Mir gr6723@wayne.edu 1 Anita Choudhary 1 Anupam Mehar 1 Harris Younas 1 Sabah Ambreen 2 Department of Internal Medicine Detroit Medical Center Wayne State University, Detroit, USA Hamdard Institute of Medical Sciences, Internal Medicine, Delhi, India Protein S deficiency is a rare thrombophilia, autosomal dominant disorder leading to VTE especially thrombosis at an uncommon place. Arterial thrombosis and strokes are very rare presentations. We are presenting a case of 19 years old lady with Beckwith Weidemann syndrome who presented with arterial thrombosis with a stroke one month prior to thrombosis. Patient was successfully managed with intravenous heparin and thrombectomy and discharged on Apixaban for life long treatment. http://pubs.sciepub.com/ajmcr/7/2/4/ajmcr-7-2-4.pdf protein S deficiency stroke arterial thrombosis