eng Science and Education Publishing American Journal of Medical Case Reports 2374-216X 2019-08-28 7 11 284 288 10.12691/ajmcr-7-11-6 AJMCR20197116 article Tariq Sharman tysharman@yahoo.com 1 Department of Medicine, Heritage College of Osteopathic Medicine, Southern Ohio Medical Center, Ohio University, Portsmouth, Ohio, USA Ehlers-Danlos syndrome (EDS) is a heterogeneous group of inherited connective-tissue disorders characterized by joint hypermobility, cutaneous fragility, and hyperextensibility. The collagen defect has been identified in at least six of the many types of Ehlers-Danlos syndrome. Changes in the mechanical properties of the bronchial airways and lung parenchyma may trigger the observed increased tendency of the airways to collapse and lung atelectasis. This is a case of a 33 year old Caucasian female who presented with acute hypoxic respiratory failure secondary to persistent right lower lobe atelectasis despite optimal medical management, pulmonary toilet, and multiple bronchoscopies. She also had an incidental finding of lung arteriovenous malformation (AVM) which can occur in EDS patients. http://pubs.sciepub.com/ajmcr/7/11/6/ajmcr-7-11-6.pdf Ehlers-Danlos atelectasis respiratory failure collapse connective tissue asthma pneumothorax arteriovenous malformation hemoptysis