eng Science and Education Publishing American Journal of Medical Case Reports 2374-216X 2019-01-22 7 1 9 12 10.12691/ajmcr-7-1-3 AJMCR2019713 article Apoorva Jayarangaiah 1 Pramod Theetha Kariyanna 2 Tanuj Chokshi 2 Maya Srinivasan 2 Seline Asun 2 Michael Ashamalla 2 Irini Youssef 2 Samy I McFarlane smcfarlane@downstate.edu 2 Department of Internal Medicine, NYC Health and Hospitals/Jacobi Medical Center, Bronx, N.Y., U.S.A- 10461 Department of Internal Medicine, State University of New York, Downstate Medical Center, Brooklyn, N.Y, U.S.A- 11203 Leukocytosis, specifically granulocytosis in malignancy is a common finding with various etiologies. Graulocytosis associated with esophageal cancer has not commonly been reported in case reports in the United States. Furthermore, granulocyte colony stimulating factor (G-CSF) producing tumors have been associated with a variety of cancers. However, G-CSF producing esophageal tumors are rare. The diagnosis is established through serum G-CSF levels and immunohistochemistry staining of tumor cells. Here, we report a case of a 72-year-old woman with persistent granulocytosis leading to the diagnosis of esophageal squamous cell carcinoma (ESCC). Although, our case did not report serum G-CSF levels, we strongly suspect it to be the underlying etiology in our case. Additionally, through our missed opportunity, we hope to emphasize and increase awareness of G-CSF producing ESCC. http://pubs.sciepub.com/ajmcr/7/1/3/ajmcr-7-1-3.pdf esophageal squamous cell carcinoma leukocytosis granulocyte colony stimulating factor (G-CSF)