eng Science and Education Publishing American Journal of Medical Case Reports 2374-216X 2017-02-11 5 1 15 21 10.12691/ajmcr-5-1-5 AJMCR2017515 article Chaozer Er erchaozer@gmail.com 1 Department of General Medicine, Tan Tock Seng Hospital, Singapore A 24-year-old Chinese lady presented with 2 weeks of fever and 1 week of cough to us after being given antibiotic by the primary care physician. Chest-X-ray showed left sided pneumonia. She undergone computed tomography of chest and bronchoscopy to investigate the non-responding pneumonia. The final diagnosis of Mycoplasma pneumoniae pneumonia (MPP) was made after the serology result turned out to be positive. Despite having being given 11 days of macrolide, she failed to achieve clinical stability till day 13 of her admission. This case demonstrated the atypical features of MPP and the importance to consider MPP as one of the differentials of non-responding pneumonia. http://pubs.sciepub.com/ajmcr/5/1/5/ajmcr-5-1-5.pdf non-responding pneumonia mycoplasma pneumoniae macrolide resistance