Science and Education Publishing American Journal of Medical Case Reports 2374-216X 4 9 2016 10 28 Varicella Related Stroke in a Patient with Systemic Lupus Erythematosus and Systemic Sclerosis Overlap 321 323 EN Fahidah Alenzi Rheumatology -King Faisal Specialist Hospital and Research Centre, Saudi Arabia Abdulrahman Al Arfaj AJMCR2016498 10.12691/ajmcr-4-9-8 2016 5 6 2016 9 9 2016 10 26 Systemic lupus erythematosus and systemic sclerosis reduce the body ability to fight infections. Although varicella zoster virus (VZV) infections are common in these diseases due to poor cellular immunity, VZV-related strokes are rare. When stroke does occur, it may be due to direct infection of the cerebral arteries, leading to a spectrum of both inflammatory and non-inflammatory pathological changes, including thrombosis. This case report is the first from the Middle East to describe a patient who developed stroke associated with herpes zoster ophthalmicus.