Science and Education Publishing American Journal of Medical Case Reports 2374-216X 4 7 2016 7 26 Vibrio Cholera Diarrohea in Neonate: A Case Report 238 239 EN Rajkumar M. Meshram Department of Pediatrics, Government medical College, Nagpur, Maharashtra, India Ashwini Patil AJMCR2016475 10.12691/ajmcr-4-7-5 2016 3 13 2016 6 23 2016 7 24 Neonatal cholera is a extremely rare in neonate. Colostrum may offer potent protection among breast fed neonates mediated by specific immunoglobulin IgA. Occurrence of cholera in a new born reflects the poor hygienic condition of the family and bad child rearing practice. As rehydration therapy and antibiotics is the main stay of treatment of this particular condition, the broader perspective is to counsel the population about hazards of prelactal feed, top feeding and good hygienic measures. We report two cases of neonatal cholera with severe dehydration.