Science and Education Publishing American Journal of Medical Case Reports 2374-216X 4 7 2016 7 13 Aggressive Angiomyxoma of the Scrotum: A Case Report and Literature Review 232 235 EN Rais Syaeful Haq Medical Faculty, Padjadjaran University, dr. Hasan Sadikin Hospital, Bandung, Indonesia Ferry Safriadi AJMCR2016473 10.12691/ajmcr-4-7-3 2016 2 18 2016 5 9 2016 7 11 Aggressive Angiomyxoma is a rare mesenchymal benign myxoid tumor of the pelvis and perineum which occurs almost exclusively in adult females. It rarely occurs in males and involves scrotum, locally infiltrative but nonmetastasizing. The clinical presentation was one of progressing scrotal edema and enlargement with subsequent development of scrotal abscesses. The clinical differential diagnosis at presentation commonly includes inguinal hernia, testicular neoplasm, spermatic cord lipoma, hydrocele, spermatocele, and scrotal filariasis. We report a case of incidentally diagnosed Angiomyxoma of scrotum presenting as scrotal edema. Case Report: A 41 years old male presented with a painless scrotal swelling since 2 years prior to admission that gradually progressed in size. Clinical examination revealed diffuse scrotal swelling measuring about 15×12cm. with a thickened of scrotal skin. Ultrasound examination report was found of fluid collection with debris in the scrotum suspected as scrotal abscess, subcutaneous edema and cutaneous scrotal wall thickening. Result: The patient underwent wide excision and scrotoplasty, the pathology result of the excised scrotal edema was an Angiomyxoma of the scrotum up to tunica vaginalis. Conclusion: Aggressive Angiomyxoma in the scrotal region may present as a scrotal edema and enlargement, often mistaken for an inguinal hernia, testicular neoplasm, spermatic cord lipoma, hydrocele, spermatocele, and scrotal filariasis.