@article{ajmcr20164710,
author={{Igbinosa, Osamuyimen and Igbinosa, Owen and Dass, Krishna and Wortmann, Glenn},
title={<i>Nocardia arthritidis</i> Infection in an Immunocompetent Human in the United States},
journal={American Journal of Medical Case Reports},
volume={4},
number={7},
pages={251--254},
year={2016},
url={http://pubs.sciepub.com/ajmcr/4/7/10},
issn={2374-216X},
abstract={Patients with T-cell defects are at the highest risk for nocardiosis, a potentially life-threatening infection caused by several species of the genus, <i>Nocardia</i>. We report a case of disseminated <i>Nocardia</i><i> arthritidis </i>in a patient who had no recognizable risk factors for immunodeficiency. A 43-year-old woman was noted to have a left upper lobe cavitary lesion on an outpatient computerized tomography (CT) scan that was performed for evaluation of pelvic congestion syndrome. She subsequently had an image-guided biopsy of the lesion, but the results were still pending when she presented at the emergency department with a transient episode of aphasia. A CT scan of the patientĄ¯s head revealed hypodensities in the right frontoparietal and left frontal lobes. A modified acid-fast stain on the lung biopsy specimen demonstrated variable, branching, filamentous bacteria with morphology consistent with <i>Nocardia</i> species. Matrix-Assisted Laser Desorption / Ionization ¨C Time-of-Flight (MALDI-TOF) Mass Spectrometry at a reference laboratory later identified the bacteria as <i>Nocardia arthritidis.</i><i> </i>This case highlights that disseminated nocardiosis can occur in an apparently healthy population. A more detailed immunologic evaluation that include screening for chronic granulomatous disease, anticytokine autoantibody deficiency and interleukin-12-gamma interferon pathway deficiency may further assist in the diagnosis of patientsĄ¯ underlying diseases.},
doi={10.12691/ajmcr-4-7-10}
publisher={Science and Education Publishing}
}