Science and Education Publishing American Journal of Medical Case Reports 2374-216X 4 5 2016 5 30 Case Report: A 12-Year History of Autoimmune Disease Systemic Lupus Erythematosus 175 179 EN Eva Kovacs-Benke Cancer Immunology Research, 4127 Birsfelden, Switzerland AJMCR2016459 10.12691/ajmcr-4-5-9 2016 1 23 2016 3 17 2016 5 28 Systemic lupus erythematosus (SLE) is a chronic, autoimmune, connective tissue disorder with multi-organ involvement. Reported here is the case of a 33-year-young women with a 12-year history of lupus erythematosus. The article documents the development of lupus: First phase/ preliminary phase (13-21 years of life); Second phase/acute cutaneous lupus erythematosus (22-27 years of life); Third phase/systemic lupus erythematosus (from 28 years of life). The parameters of serological test and blood test were measured regularly during the course of the disease. The MRI-investigation was carried out three times. The clinical symptoms are evaluated in relation to the laboratory parameters All these data with the therapeutic modalities and the trigger factor(s) are disclosed.