Dear Label_Name,

Greetings! I hope you are well.

I am writing on behalf of an international publishing house, Science and Education Publishing, USA (http://www.sciepub.com).

Science and Education Publishing (SciEP) is a multidisciplinary open access publisher of Journals covering the fields of Science, Technology and Medicine. All SciEP publications are subject to high-quality peer review, editorial and production processes and are freely available online.

Welcome to the April, 2013 edition of SciEP newsletter, providing monthly summaries of articles on science & education related topics of interest to scientist and professionals. The mission of our journals is to provide an open access forum for publishing new findings on issues pertinent to scientific and academic field. We also invite you to submit original research papers, review articles, short reports, or case studies are considered for publication in our Multidisciplinary Journals.

American Journal of Public Health Research
DOI: 10.12691/ajphr-1-1-3

The Implementation of a Tele-Homecare System with Service Oriented Architecture and HL7 Message Transmission Standard
Ching-Sung Wang

American Journal of Medical and Biological Research
DOI: 10.12691/ajmbr-1-1-2

The Influence of Ethanol on Pyruvate Kinases Activity in Vivo, in Vitro, in Silico
Lelevich Sergey Vladimirovich, Khrustalev Vladislav Victorovich, Barkovsky Eugene Victorovich, Shedogubova Tatyana Aleksandrovna

American Journal of Medical Sciences and Medicine
DOI: 10.12691/ajmsm-1-1-1

Clinical and Histological Features in Wegener Granulomatosis
Li Cavoli Gioacchino, Passantino Rita, Bono Luisa, Tortorici Calogera, Ferrantelli Angelo, Giammarresi Carlo, Rotolo Ugo

American Journal of Infectious Diseases and Microbiology
DOI: 10.12691/ajidm-1-1-2

The Curse of Lymphatic Filariasis: Would the Continual Use of Diethylcarbamazine Eliminate this Scourge in Papua New Guinea?
Anne Lanham, Lillian Mwanri

We have released issues of some journals on February 2013.
American Journal of Public Health Research
American Journal of Medical Sciences and Medicine
American Journal of Medical and Biological Research
American Journal of Pharmacological Sciences
American Journal of Clinical Medicine Research
American Journal of Nursing Research
American Journal of Cancer Prevention
American Journal of Medicine Studies
American Journal of Infectious Diseases and Microbiology
American Journal of Cardiovascular Disease Research
American Journal of Biomedical Research
American Journal of Mechanical Engineering
American Journal of Microbiological Research
Journal of Preventive Medicine
American Journal of Food and Nutrition
American Journal of Hypertension Research
American Journal of Sports Science and Medicine
Journal of Cancer Research and Treatment
American Journal of Zoological Research
Journal of Biomedical Engineering and Technology
American Journal of Microbiological Research
Biomedical Science and Engineering

We are pleased to announce that submissions are now being accepted for peer review for all the journals across all our subject areas in SciEP.

Please submit your manuscript via our online submission system:
http://www.sciepub.com/author/signin

To unsubscribe from our mailing list, please click on the following link: unsubscribe

I am looking forward to hearing from you.

Kind regards,

David Rain
Email:join@sciepub.com
Science and Education Publishing (http://www.sciepub.com)

Vertebral Osteomyleitis Caused by Candida Albicans in an IV Drug Abuser

Nagadarshini Ramagiri Vinod, Hassan Tahir*, Khandakar Hussain, Saad Ullah

Department of Internal Medicine, Temple University/Conemaugh Memorial Hospital, 1086 Franklin Street, Johnstown, PA 15905, USA

Abstract: The incidence of back pain is listed only second to upper respiratory tract infection in symptomatic reason for office visits for a physician. Diagnosing rare and serious causes of back pain may be challenging in outpatient setting. We present a 31 year old male, an IV drug abuser, presenting with severe back pain radiating to his bilateral hips due to L1-L2 Osteomylelitis secondary to Candida Albicans infection.

Keywords: candidial vertebral osteomyelitis, back pain

Citation: Nagadarshini Ramagiri Vinod, Hassan Tahir, Khandakar Hussain, Saad Ullah, Vertebral Osteomyleitis Caused by Candida Albicans in an IV Drug Abuser. American Journal of Medical Case Reports, 4 (5). 168-169. January 2016. doi:10.12691/ajmcr-4-5-6

1. Introduction

Back pain is the most common complaint by patients in outpatient set up. The challenge for clinicians is to identify the fewer patients with a significant probability of a more serious problem that requires further workup. Spondylodiscitis is a relatively unsual disease accounting for 2–7% of all cases of pyogenic osteomyelitis, with incidence varying from 1 per 100,000/year to 1 per 250,000/year [1]. The mean age for the disease incidence is 50 years, and the lower thoracic or lumbar spine is involved in 95% of patients [2]. Here we present one such challenging case who presented to us as lower back pain.

2. Case Presentation

A 31 year old male with history of drug abuse presented to emergency department with lower back pain for a month which had worsened for last 2 days. He had prviously presented to clinic for back pain, X ray lumbar spine was ordered at that time which was normal. He was prescribed painkillers and flexeril. This time back pain got worst and he developed severe lower extremity weakness. On examination there was mild tenderness at L1-L2 with no redness or warmth. Neurological examination showed power 4/5 in both extremities and areflexia but no sensory loss. MRI of the spine was performed,which showed discitis and osteomyelitis at L1-L2 with destructive endplate changes including phlegmonous change extending along the anterior cortex of L1-L2 and involving the right psoas muscle with myositis [Figure 1, Figure 2]. An approximate of 4ml of fluid was aspirated from the L1-L2 vertebra, and patient was empirically treated with I.V vancomycin. The Drained fluid was sent for culture and sensitivity which was reported positive for Yeast. Empiric treatment for Candida with I.V Micofungin 100mg daily was started. Once the final fungal culture showed Candideal Albicans growth, a loading dose of Oral Fluconazole 800 mg was given and patient was discharged home on maintenance dose of 400mg daily to be continued for 6. His symptoms continued to improve in next couple of weeks. HIV testing was also done which came back negative.

Figure 1. MRI spine showing L1- L2 Osteomylelitis

Figure 2. MRI spine showing prominent Psoas Abscess

3. Discussion

Back pain is the second most common symptom-related reason for clinician visits in the United States [3]. Up to 85 percent of adults have low back pain at some point in their lives [4]. The etiologies for Back pain has a broad spectrum. For most patients with low back pain, an accurate patho-anatomical diagnosis is often not possible, which leads to numerous imprecise diagnoses (eg: sprain or strain). Vertebral bone infections caused by fungi are not common. A recent review of vertebral osteomyelitis caused by Aspergillus species describes only 41 cases in the published literature [5]. Cases of fungal vertebral osteomyelitis caused by the endemic fungi Coccidioides immitis and Blastomyces dermatitidis have also been described [6,7]. We came across a case of vertebral osteomyelitis caused by C. Albicans in IV drug abuser and searched the medical literature for similar cases. Candida species are typically commensal organisms and are either a part of the normal human flora or associated with clinically benign infections, such as vaginitis. [8] However, in the presence of impaired host immunity as in HIV infection or repeated intravascular access as in our case with IV drug abuse, Candida species can become invasive pathogens. Other organisms which are known to cause Osteomyleitis in IV drug abusers are Staphylococcal aureus, Pseudomonas aeruginosa [1].Early detection of Candidial Lumbar Osteomyleitis is difficult unless the patient develops back pain with or without fever or Neurological deficits impending Vertebral compression or abscess formation. As soon as Vertebral Osteomyelitis is diagnosed, urgent confirmation of organism with bone biopsy or bone aspiration is necessary as treatment involves long term use of antibiotics for at least 6 weeks [1]. MRI of spine for confirmation of underlying complications like compression or Abscess formation also plays a prime role. Our patient was diagnosed with vertebral Osteomyelitis after MRI spine with contrast and aspiration of L1 L2 diskitis. Drainage culture was positive for Yeast infection. Patient was started on emperic I.V Micafungin for possible Candidial infection which was switched to oral Flucanozole once the report confirmed Candida albicans infections, which was continued for 6 months. His sumptoms resolved with the treatment.

4. Conclusion

1. Although Staphylococcus aureus is the most important infecting organism of osteomyelitis in drug users, other organisms including pseudomonas aeruginosa, candida albicans or even gram-negative bacilli can be the cause which should not be neglected in IV drug abusers.

2. Vertebral Osteomylitis should be high on diffrential diagnosis in IV drug abusers presenting to clinics with back pain. Vertebral osteomyelitis should still be considered if such patients don’t have any constitutional symptoms.

3. Early detection and appropriate treatment of Candidial Osteomyleitis with antifungals is important to prevent disabling conditions like vertebral abscess and compression.

References

[1]   | Candida albicanslumbar spondylodiscitis in an intravenous drug user: a case report- Chang-Hua Chen, Wei Liang Chen and Hua-Cheng Yen.
[2]   | Vertebral Osteomyelitis due to Candida Species: Case Report and Literature Review-David J Miller and George Mejicano.
[3]   | R. A. Deyo and Y. J. Tsui-Wu, “Descriptive epidemiology of low-back pain and its related medical care in the United States,” Spine, vol. 12, no. 3, pp. 264-268, 1987.
[4]   | J. D. Cassidy, L. J. Carroll, and P. Côté, “The Saskatchewan health and back pain survey: the prevalence of low back pain and related disability in Saskatchewan adults,” Spine, vol. 23, no. 17, pp. 1860-1867, 1998.
[5]   | Bross J, Talbot GH, Maislin G, Hurwitz S, Strom BL Risk factors for nosocomial candidemia: a case-control study in adults without leukemia. Am J Med1989;87:614-20.
[6]   | Bayer AS, Yoshikawa TT, Galpin JE, Guze JB Unusual syndrome of coccidiomycosis: diagnostic and therapeutic considerations; a report of 10 cases and review of the English literature. Medicine (Baltimore) 1976;55:131-52.
[7]   | Halpern AA, Rinshy LA, Fountain S, Nagel DA Coccidioidomycosis of the spine: unusual radiographic presentation. Clin Orthop 1979;140:78-9.
[8]   | Edwards JE Jr Candida species. In: Mandell GL, Bennett JE, Dolin R, editors.Principles and practice of infectious diseases. 4th ed. New York: Churchill Livingstone; 1985. p. 2289-306.