Dear Label_Name,

Greetings! I hope you are well.

I am writing on behalf of an international publishing house, Science and Education Publishing, USA (http://www.sciepub.com).

Science and Education Publishing (SciEP) is a multidisciplinary open access publisher of Journals covering the fields of Science, Technology and Medicine. All SciEP publications are subject to high-quality peer review, editorial and production processes and are freely available online.

Welcome to the April, 2013 edition of SciEP newsletter, providing monthly summaries of articles on science & education related topics of interest to scientist and professionals. The mission of our journals is to provide an open access forum for publishing new findings on issues pertinent to scientific and academic field. We also invite you to submit original research papers, review articles, short reports, or case studies are considered for publication in our Multidisciplinary Journals.

American Journal of Public Health Research
DOI: 10.12691/ajphr-1-1-3

The Implementation of a Tele-Homecare System with Service Oriented Architecture and HL7 Message Transmission Standard
Ching-Sung Wang

American Journal of Medical and Biological Research
DOI: 10.12691/ajmbr-1-1-2

The Influence of Ethanol on Pyruvate Kinases Activity in Vivo, in Vitro, in Silico
Lelevich Sergey Vladimirovich, Khrustalev Vladislav Victorovich, Barkovsky Eugene Victorovich, Shedogubova Tatyana Aleksandrovna

American Journal of Medical Sciences and Medicine
DOI: 10.12691/ajmsm-1-1-1

Clinical and Histological Features in Wegener Granulomatosis
Li Cavoli Gioacchino, Passantino Rita, Bono Luisa, Tortorici Calogera, Ferrantelli Angelo, Giammarresi Carlo, Rotolo Ugo

American Journal of Infectious Diseases and Microbiology
DOI: 10.12691/ajidm-1-1-2

The Curse of Lymphatic Filariasis: Would the Continual Use of Diethylcarbamazine Eliminate this Scourge in Papua New Guinea?
Anne Lanham, Lillian Mwanri

We have released issues of some journals on February 2013.
American Journal of Public Health Research
American Journal of Medical Sciences and Medicine
American Journal of Medical and Biological Research
American Journal of Pharmacological Sciences
American Journal of Clinical Medicine Research
American Journal of Nursing Research
American Journal of Cancer Prevention
American Journal of Medicine Studies
American Journal of Infectious Diseases and Microbiology
American Journal of Cardiovascular Disease Research
American Journal of Biomedical Research
American Journal of Mechanical Engineering
American Journal of Microbiological Research
Journal of Preventive Medicine
American Journal of Food and Nutrition
American Journal of Hypertension Research
American Journal of Sports Science and Medicine
Journal of Cancer Research and Treatment
American Journal of Zoological Research
Journal of Biomedical Engineering and Technology
American Journal of Microbiological Research
Biomedical Science and Engineering

We are pleased to announce that submissions are now being accepted for peer review for all the journals across all our subject areas in SciEP.

Please submit your manuscript via our online submission system:
http://www.sciepub.com/author/signin

To unsubscribe from our mailing list, please click on the following link: unsubscribe

I am looking forward to hearing from you.

Kind regards,

David Rain
Email:join@sciepub.com
Science and Education Publishing (http://www.sciepub.com)

Eosinophilic Colitis Presenting with Haemorrhagic Diarrhea

Ferda Akbay Harmandar*, Zahide Taş, Ayhan Hilmi Çekin, Seyit Uyar

Antalya Training and Research Hospital, Internal Diseases Department, Gastroenterology, Antalya, Turkey

Abstract: Eosinophilic colitis is a rare condition and very uncommonly it presents with acute surgical emergency such as haemorrhage and peritonitis. We describe a rare presentation of eosinophilic colitis with severe haemorrhage and abdominal pain with ischemic bowel.

Keywords: eosinophilic gastrointestinal disorders, eosinophilic colitis, haemorrhagic diarrhae

Citation: Ferda Akbay Harmandar, Zahide Taş, Ayhan Hilmi Çekin, Seyit Uyar, Eosinophilic Colitis Presenting with Haemorrhagic Diarrhea. American Journal of Medical Case Reports, 4 (4). 134-136. January 2016. doi:10.12691/ajmcr-4-4-6

1. Introduction

Eosinophilic gastrointestinal disorders or eosinophilic digestive disorders (EGIDs) include a spectrum of rare gastrointestinal disorders that includes eosinophilic esophagitis, eosinophilic gastroenteritis and eosinophilic colitis [1]. Eosinophilic colitis (EC) is a rare clinical entity [2]. The cilinical presentation is usually nonspecific. Severe cases may develop severe abdominal pain and distension, malabsorption, intestinal obstruction, an even gastrointestinal haemorrhage [3]. Due to the nonspecific nature of the symptoms and rarity of the condition, it is commonly diagnosed only late in presentation. We describe a 28-year old man with eosinophilic colitis presenting as haemorrhagic colitis requiring total colectomy.

2. Case Presentation

A 28 year old man presented to the hospital with complaints of a 10 day history of severe abdominal pain specially localised on right down side of abdomen and haemorrhagic diarrhea. During examination his heart rate was 104 beats per minute, blood pressure 110/70 mmHg and temperature was 37,2°C. He was oriented to person, place and time. Cardiovascular, respiratory, musculoskeletal and neurological examination were normal. Abdominal examination revealed generalized tenderness and rebound sign on the right down side of abdomen. His white blood cell count was 18.500/μl, eosinophil count was 3700/ μl (%19.8). His platelet count decreased to 79000/μl and CRP also increased to 92 mg/dl. An urgent ultrasonography of abdomen was ordered which showed terminal ileitis’ signs. On the second day of his admission, he developed increasing abdominal pain and distension. A computed tomogram (CT) of the abdomen was planed, and CT showed a small amount of ascites and a long segment of circumferential mural thickening of descending colon, sigmoid colon and rectum. Patient was consulted with the department of general surgery and he was taken to an emergency operation. Intraoperatively, there was severe haemorrhagic colitis and infarction involving nearly total colon. Total colectomy and ileostomi were performed. On total colectomy material ; 93 cm colon,5 cm ileum and 5 cm appendix was seen that haemorrhagic and fibrinoid view, and especially on sigmoid colon, bowel wall was thickened and haemorrhagic, other side of bowel was with edema, hyperemic and haemorrhagic (Figure 1).

Figure 1. Colectomy material

Histology revealed ischemic-haemorrhagic bowel with eosinophilic pancolitis and eosinophilic vasculitis with transmural haemorrhagic infarction and eosinophilic microabscesses (Figure 2).

Figure 2. Eosinophilic colitis histology

3. Discussion

Eosinophilic gastrointestinal disorders (EGID) are one of rare causes of chronic diarrhea. The disorders are characterized by inflammation rich in eosinophilic infiltration in the gastrointestinal (GI) tract without evidence of known causes for eosinophilia such as parasitic infection, drug reaction, or malignancy [1,4,5]. It was originally described by Kaijser [6] in 1937; since then, hundreds of cases have been described from all over the world including North America, Europe, Australia and Asia [7]. EGID can involve one or multiple segments of the GI tract from the esophagus to the rectum (mainly in the antrum of the stomach and small intestine) [6] and can also occupy various sites through the depth of the wall. Such inconsistency from case to case promotes unpredictable symptoms from pain to dysmotility, bleeding, obstruction, or ascites [8]. In 1990, Talley et al. [9] defined EGID by three criterias: 1) the presence of gastrointestinal symptoms, 2) biopsies showing eosinophilic infiltration of one or more areas of the gastrointestinal tract from the esophagus to the colon, or characteristic radiological findings with peripheral eosinophilia, and 3) no evidence of parasitic or extraintestinal disease. Presently, this concept is most commonly used in defining EGID. In published reports, stomach (%26-%81) and small intestine (%28-%100) are the predominantly affected sites but esophagus, large intestine, and rectum may be affected as well [7].

Significant progress has been made in elucidating that eosinophils are integral members of the gastrointestinal mucosal immune system and that eosinophilic gastrointestinal disorders are primarily polygenic allergic disorders that involve mechanisms that fall between pure IgE-mediated and delayed T(H)2-type responses. EGID affect all ages, from infancy through adulthood, peaking during the second and sixth decades of life [10]. Contrary to other subtypes, eosinophilic colitis has a bimodal age distribution, usually affecting infants (mean age, 60 days) and adolescents [11]. Although there are some differences among the reports, the incidence is higher in males, with a ratio of 3:2 [10].

The etiology of EGID remains largely unknown. Several studies have suggested a relationship with specific food allergies, and approximately 70% of patients may have a personal or family history of allergic disorders such as asthma, fever, hypersensitivity to drugs, or eczema [10]. In contrast to other EGID, eosinophilic colitis is usually a non-IgE-associated disease. Thus, skin prick test or antigen-specific IgE (RAST) is negative [12]. Some studies point to a T cell-mediated process, but the exact immunologic mechanisms for this have not been identified [13]. Similarly our case have normal total IgE and lacked immunologic evidence for allergy. Causes of EC may be divided into 2 main groups, that is, those with primary and secondary causes. Primary eosinophilic colitis is the rarest manifestation of EGID, the other more common presentations being eosinophilic esophagitis and eosinophilic gastroenteritis [14]. The disease mainly affects the pediatric population, although it has been reported in the adult population as well. The hallmarks of EC are peripheral eosinophilia, segmental eosinophilic colonic infiltration, and functional abnormalities [13]. Secondary causes of EC include parasitic infection, inflammatory bowel disease, carcinoma, connective tissue disease, drug-related causes such as Rifampicin, Clozapine, and Carbamazepine, and vasculitic causes. Clinical presentation of the primary EC depends on the layer of intestinal wall that is infiltrated by eosinophils and correlates well with the physical symptoms and clinical findings. Mucosal predominant disease presents with diarrhea, protein wasting, and malabsorption [15]. Transmural disease is associated with thickened bowel, obstruction, perforation, volvulus, intussusception [16], and perforation [17]. Serosal involvement is characterized by presence of eosinophilic ascites [18]. The diagnosis of EC is made via the presence of symptoms, peripheral eosinophilia, endoscopic or histological findings, and eosinophilic ascites, with exclusion of all other causes of secondary eosinophilia. Histological findings show eosinophilic infiltrates throughout the lamina propria, with extension through the muscularis mucosa into the submucosa. Crypt abscesses and lymphonodular hyperplasia may also be evident [19].

Treatment of EGID can be divided into dietary modifications and pharmacotherapy. Food allergy testings and elimination and elemental diets should be considered and often are performed before a trial of corticosteroids. Corticosteroids are the mainstay of therapy and most patients have symptomatic response [1,16,20]. Treatment of EC has not been well established because of the low numbers of reported cases. In neonates, there has been some beneficial effect of withdrawing specific food triggers for cases with food allergies; however, in adults, the response of dietary modification is less clearer. In patients who present with abdominal symptoms, firstly, indications for surgical exploration must be ruled out, such as free intraabdominal air, volvulus, obstruction, or peritonitis. In all other patients with no such indications, corticosteroids have been found to be effective for symptom control in EC [21]. The majority of cases respond within 2 weeks of treatment; however, relapse is frequent and may require recurrent courses which may lead to steroid dependence. Budesonide has been shown to be effective in cases of EC, particularly in the right colon [21].

Eosinophilic colitis is seen very rarely. It may present acutely and may lead to surgical exploration because of the severe and fatal complications like haemorrhage and perforation. Early diagnosis and appropriate treatment is very important in such patients.

References

[1]   | Khan S, Orenstein SR. Eosinophilic gastroenteritis: epidemiology, diagnosis and management. Paediatr Drugs 2002;4:563-70.
[2]   | N. Okpara, B. Aswad, and G. Baffy, “Eosinophilic colitis,” World Journal of Gastroenterology, vol. 15, no. 24, pp. 2975-2979, 2009.
[3]   | G. Y. Ong, C. C. Hsu, C. S. Changchien, S. N. Lu, and S. C. Huang, “Eosinophilic gastroenteritis involving the distal small intestine and proximal colon,” Chang Gung Medical Journal, vol. 25, no. 1, pp. 56-61, 2002.
[4]   | Rothenberg ME. Eosinophilic gastrointestinal disorders (EGID). J Allergy Clin Immunol 2004;113:11-28.
[5]   | Yan BM, Shaffer EA. Primary eosinophilic disorders of the gastrointestinal tract. Gut 2009;58:721-32.
[6]   | Dong-Ryull Lee. A Case of Eosinophilic Gastrointestinal Disorders Presenting with Chronic Diarrhea and Abdominal Pain. Korean J Fam Med. 2011; 32: 257-62
[7]   | Feldman M, Scharschmidt B, Sleisenger M. Sleisenger and Fordtran's gastrointestinal and liver disease. 6th ed. Philadelphia: Saunders; 2006.
[8]   | Cello JP. Eosinophilic gastroenteritis: a complex disease entity. Am J Med 1979;67:1097-104.
[9]   | Talley NJ, Shorter RG, Phillips SF, Zinsmeister AR. Eosinophilic gastroenteritis: a clinicopathological study of patients with disease of the mucosa, muscle layer, and subserosal tissues. Gut 1990; 31:54-8.
[10]   | Khan S, Orenstein SR. Eosinophilic gastroenteritis: epidemiology, diagnosis and management. Paediatr Drugs 2002;4: 563-70.
[11]   | Guajardo JR, Rothenberg ME. Eosinophilic esophagitis, gastroenteritis, gastroenterocolitis, and colitis. 3rd ed. Malden, MA: Blackwell Publishing; 2003.
[12]   | Conus S, Simon HU. General laboratory diagnostics of eosinophilic GI diseases. Best Pract Res Clin Gastroenterol 2008; 22:441-53.
[13]   | M. E. Rothenberg, “Eosinophilic gastrointestinal disorders (EGID),” Journal of Allergy and Clinical Immunology, vol. 113, no. 1, pp. 11-28, 2004.
[14]   | J. R. Guajardo, L. M. Plotnick, J. M. Fende, M. H. Collins, P. E. Putnam, and M. E. Rothenberg, “Eosinophil-associated gastrointestinal disorders: a world-wide-web based registry,” Journal of Pediatrics, vol. 141, no. 4, pp. 576-581, 2002.
[15]   | R. E. Clouse, D. H. Alpers, D. M. Hockenbery, and K. DeSchryver-Kecskemeti, “Pericrypt eosinophilic enterocolitis and chronic diarrhea,” Gastroenterology, vol. 103, no. 1, pp. 168-176, 1992.
[16]   | W. G. Shin, C. H. Park, Y. S. Lee et al., “Eosinophilic enteritis presenting as intussusception in adult,” Korean Journal of Internal Medicine, vol. 22, no. 1, pp. 13-17, 2007.
[17]   | O. Minciu, D. Wegmann, and J. O. Gebbers, “Eosinophiliccolitis-a rare cause of acute abdomen,” Schweizerische Medizinische Wochenschrift, vol. 122, no. 38, pp. 1402–1408, 1992.
[18]   | L. P. Kravis, M. A. South, and M. L. Rosenlund, “Eosinophilic gastroenteritis in the pediatric patient,” Clinical Pediatrics, vol. 21, no. 12, pp. 713-717, 1982.
[19]   | J. Guajardo and M. E. Rothenberg, “Eosinophilic esophagitis, gastroenteritis, gastroenterocolitis and colitis,” in Food Allergy: Adverse Reactions of Foods and Additives, pp. 217-226, Blackwell Publishing, Oxford, UK, 2008.
[20]   | Nneka Ekunno, DO, MPH, Kirk Munsayac, DO, Allen Pelletier, MD and Thad Wilkins, MD, Eosinophilic Gastroenteritis Presenting with Severe Anemia and Near Syncope. J Am Board Fam Med 2012, 25: 913-18
[21]   | Shen-Ann Eugene Yeo, Yon Kuei Lim, Kiat Hon Tony Lim, Choong-Leong Tang, Toxic Haemorrhagic Colitis: A rare Presentationh of Eosinophilic Colitis. Hindawi Publishing Corporation Case Reports in Gastrointestinal Medicine Volume 2012.