Science and Education Publishing American Journal of Medical Case Reports 2374-216X 4 2 2016 2 24 Type 1 Cryoglobulinemia in Monoclonal Gammopathy Presenting as Acute Renal Failure and Fatal Outcome 44 47 EN Orivaldo Alves Barbosa Internal Medicine Department, Hospital Cesar Cals Herivaldo Ferreira da Silva Priscila Dourado Evangelista José Gerardo Araujo Paiva Cristiane Ferreira da Silva João Paulo Uchoa Fontenele José Walter Correia AJMCR2016423 10.12691/ajmcr-4-2-3 2015 10 12 2016 1 30 2016 2 22 The cryoglobulinemia , particularly type 1 or monoclonal, is a rare disease with variable severity and diverse clinical manifestations and may lead to death due to multisystem failure and secondary infections. The early recognition and treatment of this disease are essential for a good prognosis. We report a case of cryoglobulinemic disease associated with Monoclonal gammopathy of Undetermined Significance with fatal outcome.