eng Science and Education Publishing American Journal of Medical Case Reports 2374-216X 2016-02-24 4 2 44 47 10.12691/ajmcr-4-2-3 AJMCR2016423 article Orivaldo Alves Barbosa orivaldo.alves.barbosa@gmail.com 1 Herivaldo Ferreira da Silva 2 Priscila Dourado Evangelista 3 José Gerardo Araujo Paiva 3 Cristiane Ferreira da Silva 4 João Paulo Uchoa Fontenele 5 José Walter Correia 5 Internal Medicine Department, Hospital Cesar Cals Hematology Department, Hospital Cesar Cals Rheumatology Department, Hospital Cesar Cals Academic of Medicine Pathologist, Argos Laboratory The cryoglobulinemia , particularly type 1 or monoclonal, is a rare disease with variable severity and diverse clinical manifestations and may lead to death due to multisystem failure and secondary infections. The early recognition and treatment of this disease are essential for a good prognosis. We report a case of cryoglobulinemic disease associated with Monoclonal gammopathy of Undetermined Significance with fatal outcome. http://pubs.sciepub.com/ajmcr/4/2/3/ajmcr-4-2-3.pdf monoclonal gammopathies cryoglobulinemic vasculitis cryoglobulinemia livedo reticularis