eng Science and Education Publishing American Journal of Medical Case Reports 2374-216X 2016-12-23 4 12 376 377 10.12691/ajmcr-4-12-2 AJMCR20164122 article Smita Subramaniam Drsmitamd@Hotmail.com 1 Bassam Ghabach 1 Andrey Manov 1 Department of Internal Medicine, JPS Hospital [John Peter Smith], Fort Worth, Texas USA Pituitary and suprasellar lesions can cause diabetes insipidus due to interruption of pathways carrying vasopressin and oxytocin to pituitary. Central diabetes insipidus is characterized by polyuria and polydipsia and is a direct result of deficiency of vasopressin. Midline mass lesions in brain and body warrant further workup for possible diagnosis of germ cell tumors. We present an interesting case of a young man with suprasellar brain lesion and diabetes insipidus with pan hypopituitarism where further workup revealed germinoma. Patient had a favorable outcome with surgery followed by radiation therapy. http://pubs.sciepub.com/ajmcr/4/12/2/ajmcr-4-12-2.pdf diabetes insipidus germ cell tumor panhypopituitarism