Science and Education Publishing American Journal of Medical Case Reports 2374-216X 4 11 2016 12 21 MRSA: An Emerging Cause of Prostate Abscess 368 370 EN Zeeshan Khakwani Department of Internal Medicine, Conemaugh Memorial Medical Center, Johnstown, PA, USA Asad Ullah AJMCR20164115 10.12691/ajmcr-4-11-5 2016 8 15 2016 10 5 2016 12 19 Gram negative bacteria are the most common cause of acute prostatitis and prostate abscess. Increased empiric use of antibiotics and immunocompromised states, predispose patients to develop invasive prostate infections due to uncommon organisms like Community acquired methicillin resistant staphylococcus aureus (CA-MRSA). Prostatitis and prostate abscess, classically, result in significant constitutional symptoms including dysuria, fevers and irritative urinary symptoms along with pelvic pain. We present a rare case of acute prostatitis secondary to MRSA, with minimal constitutional symptoms, complicated with formation of prostate abscess and sepsis requiring surgical intervention.