Science and Education Publishing American Journal of Medical Case Reports 2374-216X 4 10 2016 11 1 Unicentric Mixed Variant Castleman Disease Associated with Brachiocephalic Vein Thrombosis: A Rare Presentation 339 342 EN Imene Boukhris Internal Medicine Department, University hospital of Charles Nicolle, Tunis, Tunisia Hana Zoubaidi Ines Kechaou Eya Cherif Nadia Znaidi Aicha Ben Miled Narjes Khalfallah AJMCR20164103 10.12691/ajmcr-4-10-3 2016 5 22 2016 10 8 2016 10 30 Castleman disease (CD) is an uncommon lymphoproliferative disorder occurring mostly in patients presenting with mediastinal lymphadenopathy. Predominant phenotypes are categorized as localized hyaline vascular or multicentric plasma cell variants. Localized form of CD is usually asymptomatic and rarely associated with deep venous thrombosis. We report an exceptional case of mediastinal CD, which presented as retrosternal chest pain, in a 42-year old man. Imaging and pathological examination showed an atypical, mixed and localized form of CD. Thoracic CT scan revealed brachiocephalic vein thrombosis. Investigations didn't reveal other risk factors for deep venous thrombosis. Deep venous thrombosis is an exceptional complication of localized variants of CD. Therefore, it seems worth looking carefully for this last type of benign lymphopathy when an unusual thrombosis is found.