Science and Education Publishing American Journal of Medical Case Reports 2374-216X 4 1 2016 2 2 Biatrial Cardiac Myxoma: A Case Report 22 25 EN Mohammad Reza AghajankhahTamijani Department of Cardiology, Heshmat Cardiovascular Research Center, Guilan University of Medical Sciences, Rasht, Iran AJMCR2016417 10.12691/ajmcr-4-1-7 2015 9 1 2015 12 24 2016 1 31 A 37 years old man presented with acute ataxia and vertigo. An axial brain CT Scan without contrast showed multiple subcortical hyperdence lesions. Brain MRI with gadolinium showed multiple hyperintence lesions. Transthoracic echocardiography showed large mobile biatrial masses. Biatrial masses were resected surgically. Both tumors had the histopathological features of benign cardiac myxoma. The clinical diagnosis was multiple brain emboli from cardiac myxoma. Myxoma is a primary benign cardiac tumor with a reported incidence of 0.0017% among the general population. The patient may present with constitutional symptoms, sequelae of valvular obstruction, embolic events or sudden death. Early diagnosis and treatment of these life threatening neoplasms is the challenge for physicians. Myxomas which arise from two different cardiac chambers are uncommon.