Science and Education Publishing American Journal of Medical Case Reports 2374-216X 4 1 2016 1 21 A Case of Periprocedural Discontinuation of Apixaban Resulting in Intra-aortic Thrombosis 16 18 EN Sabu John Pramod Theetha Kariyanna Department of Internal Medicine, State University of New York, Downstate Medical Center, Brooklyn, New York, U.S.A. Jonathan Marmur Kamal Preet Singh Mary Mallappallil AJMCR2016415 10.12691/ajmcr-4-1-5 2015 8 7 2015 12 10 2016 1 19 Apixaban, a novel oral anticoagulant is approved for anticoagulation in non-valvular atrial fibrillation. Apixaban is found to be superior to warfarin in prevention of stroke and thromboembolism and is associated with lesser risk of bleeding. Peri-procedural discontinuation of apixaban is safe, but the risk of thrombosis exists. We here present a case of arterial thrombosis that lead to lower limb ischemia upon periprocedural discontinuation of apixaban.