Science and Education Publishing American Journal of Medical Case Reports 2374-216X 3 9 2015 08 24 Extra-Ocular Sebaceous Carcinoma of the Skin: A Report of Five Cases and a Review of the Literature 291 296 EN Mariem MOHAMED Dermatology Department, Fattouma Bourguiba University Hospital, Monastir, Tunisia Lobna BOUSSOFARA Abdlefaddeh SLAMA Mohamed DENGUEZLI Colandane BELAJOUZA Bedreddine SRIHA Najet GHARIANI Rafiaa NOUIRA AJMCR2015398 10.12691/ajmcr-3-9-8 2015 07 23 2015 08 05 2015 08 24 Background: Extra ocular sebaceous carcinoma is a rare aggressive adnexal tumour. The diagnosis of this tumour is difficult due to the variety of its clinical and histopathological features. The prognosis is actually considered as aggressive as the ocular counterpart. Methods and results: We propose to discuss the clinical features, histopathological findings and aggressive potential of extra ocular sebaceous carcinoma. Therefore, five extra ocular sebaceous carcinoma cases, diagnosed at the Dermatology and Pathology departments of Farhat Hached Hospital, from January 1998 to December 2007, were reviewed. The diagnosis was based on a histopathological examination. Three of them developed locoregional and/or distant metastases. One patient died from metastatic disease. Surgery was the mainstay of treatment without any cutaneous recurrence after a mean follow-up of two years. Conclusions: Extra ocular sebaceous carcinoma has an unpredictable prognosis. It can be highly aggressive and cause death. Surgery remains the mainstay of treatment.