eng Science and Education Publishing American Journal of Medical Case Reports 2374-216X 2015-08-24 3 9 291 296 10.12691/ajmcr-3-9-8 AJMCR2015398 article Mariem MOHAMED mariemmohamed79@yahoo.fr 1 Lobna BOUSSOFARA 2 Abdlefaddeh SLAMA 3 Mohamed DENGUEZLI 3 Colandane BELAJOUZA 3 Bedreddine SRIHA 4 Najet GHARIANI 4 Rafiaa NOUIRA 4 Dermatology Department, Fattouma Bourguiba University Hospital, Monastir, Tunisia Dermatology Departments, Farhat Hached University Hospital, Sahloul University Hospital, Sousse, Tunisia Oral and Maxillo-Facial Surgery Department, Sahloul University Hospital, Sousse, Tunisia Pathology Departments, Farhat Hached University Hospital, Sahloul University Hospital, Sousse, Tunisia Background: Extra ocular sebaceous carcinoma is a rare aggressive adnexal tumour. The diagnosis of this tumour is difficult due to the variety of its clinical and histopathological features. The prognosis is actually considered as aggressive as the ocular counterpart. Methods and results: We propose to discuss the clinical features, histopathological findings and aggressive potential of extra ocular sebaceous carcinoma. Therefore, five extra ocular sebaceous carcinoma cases, diagnosed at the Dermatology and Pathology departments of Farhat Hached Hospital, from January 1998 to December 2007, were reviewed. The diagnosis was based on a histopathological examination. Three of them developed locoregional and/or distant metastases. One patient died from metastatic disease. Surgery was the mainstay of treatment without any cutaneous recurrence after a mean follow-up of two years. Conclusions: Extra ocular sebaceous carcinoma has an unpredictable prognosis. It can be highly aggressive and cause death. Surgery remains the mainstay of treatment. http://pubs.sciepub.com/ajmcr/3/9/8/ajmcr-3-9-8.pdf sebaceous adenocarcinoma extra ocular sebaceous carcinoma skin cancer prognosis surgery