Science and Education Publishing American Journal of Medical Case Reports 2374-216X 3 9 2015 08 04 Recurrent Oral Melanoma: A Case Report and Challenges in Management in Poor Resource Economy 282 285 EN Olufemi O Ariyibi Olufemi K Ogundipe Babatunde M Duduyemi Department of Pathology, Kwame Nkrumah University of Science & Technology, Kumasi, Ghana AJMCR2015395 10.12691/ajmcr-3-9-5 2015 04 14 2015 06 15 2015 08 04 Oral melanoma is a rare aggressive neoplasm which accounts for only 0.2-8% of all reported malignant melanomas. The common sites of its occurrence are the palate and gingiva with the maxillary arch being affected 80% of the time. Because of their presence at relatively obscure areas in the oral cavity, most of the malignant melanomas of the oral cavity are diagnosed at a late stage. We report a case of oral melanoma in a 55-year-old post-menopausal woman who had surgical excision followed by chemo-radiation but suffered recurrence. The challenges of management and the poor prognosis of the case are emphasized in this case report.