eng Science and Education Publishing American Journal of Medical Case Reports 2374-216X 2015-07-16 3 8 250 254 10.12691/ajmcr-3-8-8 AJMCR2015388 article Shuichi Tsubura tshu@ucatv.ne.jp 1 Yoshie Waki 2 Tsutomu Tsubura 2 Department of Biochemistry, Nippon Dental University School of Life Dentistry at Niigata, Hamaura-cho, chuo-ku, Niigata, Japan Tsubura Dental Clinic, Utsunomiya, Tochigi, Japan Abnormalities of symptomatic inflammatory tongue (SIT) present a diagnostic and therapeutic dilemma for clinicians. In particular, atrophic glossitis or fissured tongue is often linked to underlying semi-pathological conditions such as immunodeficiency, nutritional deficiency, or the effects of pharmacotherapy. The various therapies for this condition include corticosteroid ointment, anesthetic gel, anti-inflammatory drugs, and vitamin B12 supplementation to address the symptoms. However, none of these treatments has been evaluated rigorously. The case of an adult patient in which persistent, painful SIT was successfully treated using a 32% fucose chewable tablet is presented. In this case, PC-320TM achieved marked improvements in SIT. Clinical trials are needed to confirm the efficacy and safety of topical PC-320 in treating SIT. http://pubs.sciepub.com/ajmcr/3/8/8/ajmcr-3-8-8.pdf tongue fucoidan inflammation treatment tablet