Science and Education Publishing American Journal of Medical Case Reports 2374-216X 3 8 2015 06 29 Central Mucoepidermoid Carcinoma of Mandible: A Case Report 235 238 EN Nafise Shamloo Oral & Maxillofacial Pathology Department, Shahid Beheshti University of Medical Sciences, Tehran, Iran Nasim taghavi Majid nemati Yaser safi AJMCR2015384 10.12691/ajmcr-3-8-4 2015 05 11 2015 05 25 2015 06 29 Central mucoepidermoid carcinoma (CMC) is an uncommon tumor, comprising 2-3 % of all mucoepidermoid carcinomas reported. The majority of cases occurring in the 4th and 5th decades of life and they are histologically low-grade malignant neoplasm usually affecting the mandible. The case presented is a 41 year old woman with central mucoepidermoid carcinoma at the left posterior of the mandible as a swelling with purulent discharge since last year. Radiographic examination showed a radiolucent lesion with well-defined borders in distal area of ┌8.