Science and Education Publishing American Journal of Medical Case Reports 2374-216X 3 8 2015 07 21 Primary Splenic Diffuse Large B Cell Lymphoma after Splenectomy: A Rare Case with Literatur Review 265 268 EN Semra Ayturk Mehmet Celik Department of Internal Medicine, Division of Endocrinology and Metabolism, Trakya Medical School, University of Trakya, Edirne, Turkey Onur Mert Nuray Can Atakan Sezer Sibel Guldiken Ahmet Muzaffer Demir AJMCR20153811 10.12691/ajmcr-3-8-11 2015 06 27 2015 07 13 2015 07 21 Primary splenic diffuse large B cell lymphoma is rarely clinical entity and comprises 1% of all malignant lymphomas. The spleen is also involved in immune defense against blood-borne antigens. Though the haematological malignancies, spleen is usually affected as a part of multisystemic involvement rather than isolated involvement. More than half of patients affected by Hodgkin's disease and about a third of those with non-Hodgkin lymphoma have splenic involvement. The involved spleen may be complicated with rupture due to massive splenomegaly, which may need urgent intervention. In this report, we present a 47-year-old female patient with massive splenomegaly, who was diagnosed with primary splenic diffuse large B cell lymphoma after splenectomy.