eng Science and Education Publishing American Journal of Medical Case Reports 2374-216X 2015-07-21 3 8 265 268 10.12691/ajmcr-3-8-11 AJMCR20153811 article Semra Ayturk 1 Mehmet Celik drmehmetcelik@hotmail.com 1 Onur Mert 2 Nuray Can 3 Atakan Sezer 4 Sibel Guldiken 4 Ahmet Muzaffer Demir 5 Department of Internal Medicine, Division of Endocrinology and Metabolism, Trakya Medical School, University of Trakya, Edirne, Turkey Department of Internal Medicine, Trakya Medical School, University of Trakya, Edirne, Turkey Department of Pathology, Trakya Medical School, University of Trakya, Edirne, Turkey Department of General Surgery, Trakya Medical School, University of Trakya, Edirne, Turkey Department of Internal Medicine, Division of Hematology, Trakya Medical School, University of Trakya, Edirne, Turkey Primary splenic diffuse large B cell lymphoma is rarely clinical entity and comprises 1% of all malignant lymphomas. The spleen is also involved in immune defense against blood-borne antigens. Though the haematological malignancies, spleen is usually affected as a part of multisystemic involvement rather than isolated involvement. More than half of patients affected by Hodgkin's disease and about a third of those with non-Hodgkin lymphoma have splenic involvement. The involved spleen may be complicated with rupture due to massive splenomegaly, which may need urgent intervention. In this report, we present a 47-year-old female patient with massive splenomegaly, who was diagnosed with primary splenic diffuse large B cell lymphoma after splenectomy. http://pubs.sciepub.com/ajmcr/3/8/11/ajmcr-3-8-11.pdf diffuse large B-cell lymphoma splenomegaly splenic neoplasms