Science and Education Publishing American Journal of Medical Case Reports 2374-216X 3 7 2015 06 12 Giant Sigmoid Lipoma with Bowel Intussusception 216 217 EN Lakshmi Kant Pathak Assistant Professor of Medicine, University of North Dakota, Sanford Hospital, Fargo, USA Chirag Chavda Vimala Vijayaraghavan AJMCR2015379 10.12691/ajmcr-3-7-9 2015 05 31 2015 06 05 2015 06 12 Colonic lipomas are rare mesenchymal tumors that are usually asymptomatic but occasionally can cause acute presentation with GI bleed and intussusception in adults. There overall incidence of this complication is less than 1 %. Most are less than 5 cm and the largest reported in literature is of 10 cm .This case reports a giant colonic lipoma measuring 10x8 cm causing Colo-colonic intussusception. Such large lesions have increased incidence of complications and often are confused with malignancy.