eng Science and Education Publishing American Journal of Medical Case Reports 2374-216X 2015-05-08 3 6 155 157 10.12691/ajmcr-3-6-1 AJMCR2015361 article Dhrubajyoti Bandyopadhyay drdhrubajyoti87@gmail.com 1 Vijayan Ganesan 2 Debarati Bhar 2 Sibnarayan Sasmal 2 Adrija Hajra 3 Cankatika choudhury 3 Diptak Bhowmick 3 Partha Sarathi Karmakar 3 Department of accident and emergency, Lady Hardinge Medical College, New Delhi Department of Internal Medicine, RG Kar Medical College, Kolkata Department of Internal Medicine, IPGMER, Kolkata 15 years aged young girl was admitted with acute pain abdomen with distension, vomiting and fever. Patient was very sick and investigations, both blood and imaging of abdomen were suggestive of pancreatitis. This acute condition was soon followed by acute nephritis within a day or two and was established due to systemic lupus erythematosus through various investigations. Then we started treatment with high dose steroid and patient showed dramatic improvement. As a rare complication of SLE, acute pancreatitis presents as generalized flare-ups in most patients previously diagnosed with SLE. But acute pancreatitis as an initial feature of a multisystem disorder of SLE is rare and physician should remain aware of this clinical entity. http://pubs.sciepub.com/ajmcr/3/6/1/ajmcr-3-6-1.pdf systemic lupus erythematosus (SLE) acute pancreatitis lupus nephritis