@article{ajmcr2015357,
author={{Manuel, Racosta Juan and Lynn, McEwan and Carlos, Kremenchutzky Marcelo and Anne, Morrow Sarah},
title={Facial Herpes Simplex Virus Type 1 Infection in a Patient with Multiple Sclerosis on Fingolimod},
journal={American Journal of Medical Case Reports},
volume={3},
number={5},
pages={144--145},
year={2015},
url={http://pubs.sciepub.com/ajmcr/3/5/7},
issn={2374-216X},
abstract={Fingolimod is an oral disease-modifying therapy for relapsing multiple sclerosis widely used in Canada as a second-line therapy. Fingolimod increases the risk of infections given its dose-dependent reduction of peripheral lymphocytes, due to the reversible sequestration in lymphoid tissues. We present a case of disseminated facial Herpes Simplex Virus type I infection in a patient using fingolimod, with an atypical distribution of the eruption, likely due to the concomitant exposure to sunlight and application of sunscreen. This case report provides insight about a novel mechanism of disseminationof Herpes Simplex Virus type I, which generally enters damaged epithelium or mucosal surfaces secondary to abrasions or trauma. Since Herpes Simplex Virus type I infection tends to disseminate and is accompanied by visceral involvement in immunosuppressed patients, close surveillance of viral infections and the prompt administration of full-dose antiviral therapy in this population is advised.},
doi={10.12691/ajmcr-3-5-7}
publisher={Science and Education Publishing}
}