Science and Education Publishing American Journal of Medical Case Reports 2374-216X 3 2 2015 01 23 Pseudotumor Gastric AL Type Amyloidosis Mimicking Malignancy. A Case Report 46 48 EN Imed Ben Ghorbel Department of Internal Medicine, University Hospital of La Rabta, Rue Jebel Lakhdar, 1002 Tunis, Tunisia Nabil BelFeki Thouraya Ben Salem Mohamed Habib Houman AJMCR2015328 10.12691/ajmcr-3-2-8 2014 12 24 2015 01 20 2015 01 23 Amyloidosis is an abnormal extracellular deposition of insoluble proteins, which is associated with an involvement of the gastrointestinal tract in 50 to 70% of cases. In primary amyloïdosis (light chain amyloïdosis), localized gastric involvement is a rare finding which can mimick malignancy. We report the case of a 75-year-old woman, admitted with upper digestive outlet obstruction and generalized edema. Upper endoscopy revealed fundic burgeoning ulcerative process. Gastric biopsy concluded to AL type amyloidosis and no malignant tumor was found. Etiological treatment consisted of melphalan and prednisone every 6 weeks. The patient improved from her gastric complaints, and edema. The current decline is 24 months.