Science and Education Publishing American Journal of Medical Case Reports 3 2 2015 01 21 A Serious Diagnosis often Missed: Salicylate Induced Pulmonary Edema (SIPE) 37 39 EN Lakshmi Kant Pathak Department of Medicine, Sanford Medical Center University of North Dakota, USA Vimala Vijayaraghavan Chirag Chavda AJMCR2015325 10.12691/ajmcr-3-2-5 2015 01 10 2015 01 17 2015 01 21 Salicylate induced pulmonary edema is mostly a un recognized diagnosis as most physicians have little or no experience in treating it. Therefore there are only 140 possible case reports of SIPE in literature making it a rare entity. Failure to recognize this condition may lead to significant morbidity and mortality. Therefore the objective of this case report is to make aware of the possibility of this diagnosis in patients presenting with neurological changes, fever, and dyspnea and anion-gap metabolic acidosis. It also discusses the best current practice guidelines on treatment of this condition based on present literature. A more definitive guideline on its diagnosis and treatment needs further research and study.