Science and Education Publishing American Journal of Medical Case Reports 3 2 2015 01 21 Hypoglyceamia due to Paranoeplastic Secretion of Insulin in a Patient with Metastasizing Colon Cancer 34 36 EN Nadia Charfi Lilia Affes Mouna Elleuch Departement of Endocrinology, Diabetolgy, Hedi Chaker Hospital, Sfax, Tunisia Wafa Ben Saada Nabila Rkik Faten Hadj Kacem Mouna Mnif Fatma Mnif Mohamed Abid AJMCR2015324 10.12691/ajmcr-3-2-4 2014 12 31 2015 01 16 2015 01 21 Paraneoplastic hypoglycemia by insulin secreting is rarely described in literature. We review rare cases of paraneoplastic hypoglycemia due to insulin secreting non islet cell tumor diagnosed in a 51 years old patient. This man has an advanced colon cancer with hepatic metastasize. He was admitted in our department for frequent, severe, organic hypoglycemia. Hormonal finding showed elevated serum levels of insulin and c peptide associated with normal serum levels of IGF1 and IGF2. The patient was treated by diet, prednisolone, diazoxid and the metastasize was surgically removed. So that, Hypoglycemia disappeared quickly after the treatment.