Science and Education Publishing American Journal of Medical Case Reports 2374-216X 3 12 2015 11 24 Uncommon Presentation of Non-Hodgkin's Lymphoma of Maxillary Sinus: A Case Report 410 412 EN Taoufik Adouly Department of ENT, 20 ao?t Hospital, Ibn Rochd University Hospital; Casablanca, Morocco Choaib Adnane Tarek Oubahmane Sami Rouadi Redallah Abada Mohamed Roubal Mohamed Mahtar AJMCR20153127 10.12691/ajmcr-3-12-7 2015 7 10 2015 9 9 2015 11 22 Non-Hodgkin's Lymphoma is a group of neoplasms that originate from the cells of the lymphoreticular system. In 40% of cases, it arises from extranodal sites. The nasal cavities and paranasal sinuses are rarely affected by primary Non hodgkin's lymphoma. We report the case of a 60-year-old man admitted for Non-Hodgkin's Lymphoma of maxillary sinus. CT scan demonstrated an extensive lesion destroying the medial and anterior walls. The patient received 6 cycles of the chemotherapy. The follow-up for the last 1 year was normal without recurrence. The difficulty encountered in the diagnosis of this clinicopathological entity owing to its radiological and clinical expression, particularly the evolution was discussed. Though rare, the signs and symptoms of the case suggest that Non hodgkin's lymphoma should be considered in the differential diagnosis of nasal cavity lesions.