Science and Education Publishing American Journal of Medical Case Reports 2374-216X 3 10 2015 09 07 Exceptional Cause of Massive Lymph Node Enlargement: Primary Localized Amyloidosis 319 321 EN Imene Boukhris Internal Medicine Department, University hospital of Charles Nicolle, Tunis, Tunisia Samira Azzabi Ines kechaou Eya Chérif Chékib Kooli Nédia Znaidi Lamia Ben Hassine Narjess Khalfallah AJMCR20153104 10.12691/ajmcr-3-10-4 2015 06 26 2015 08 25 2015 09 07 Amyloidosis is very rarely the cause of lymph node enlargement. In the localized form of the disease, amyloidosis commonly attains the bladder, the lung and the skin. Lymph node amyloid deposition is very unusual in the localized form of the disease. In particular, cervical and mediastinal sites are uncommon. We report an exceptional case of primary localized AL amyloidosis presenting as generalized lymph node enlargement. Our patient was initially treated by colchicine but in front of disease progression, a treatment with prednisone and melphalan was necessary for stabilization. Clinician should consider primary amyloidosis in the check-list of etiologies causing lymph node enlargement.