eng Science and Education Publishing American Journal of Medical Case Reports 2374-216X 2015-09-07 3 10 319 321 10.12691/ajmcr-3-10-4 AJMCR20153104 article Imene Boukhris imen.boukhris@laposte.net 1 Samira Azzabi 1 Ines kechaou 1 Eya Chérif 1 Chékib Kooli 1 Nédia Znaidi 2 Lamia Ben Hassine 2 Narjess Khalfallah 2 Internal Medicine Department, University hospital of Charles Nicolle, Tunis, Tunisia Department of Diagnostic Pathology, University hospital of Charles Nicolle, Tunis, Tunisia Amyloidosis is very rarely the cause of lymph node enlargement. In the localized form of the disease, amyloidosis commonly attains the bladder, the lung and the skin. Lymph node amyloid deposition is very unusual in the localized form of the disease. In particular, cervical and mediastinal sites are uncommon. We report an exceptional case of primary localized AL amyloidosis presenting as generalized lymph node enlargement. Our patient was initially treated by colchicine but in front of disease progression, a treatment with prednisone and melphalan was necessary for stabilization. Clinician should consider primary amyloidosis in the check-list of etiologies causing lymph node enlargement. http://pubs.sciepub.com/ajmcr/3/10/4/ajmcr-3-10-4.pdf amyloidosis lymphadenopathy Localized