Science and Education Publishing American Journal of Medical Case Reports 2 6 2014 06 24 Diarrhea, Demyelinating Neuropathy and Dyspnea: An Occam's Razor Dilemma 117 119 EN Abimbola Aderinto-Adike Houston Methodist Hospital, Department of Medicine, 6565 Fannin Street, Houston TX 77030 USA Hung Q Doan Cima Nowbakht Elizabeth Looke-Stewart Soma Jyothula AJMCR2014262 10.12691/ajmcr-2-6-2 2014 06 05 2014 06 18 2014 06 24 POEMS disease is a rare paraneoplastic syndrome resulting from an underlying plasma cell disorder. We present a unique case of POEMS disease with predominant clinical symptoms of diarrhea and paresthesias.