Science and Education Publishing American Journal of Medical Case Reports 2 10 2014 10 24 Unusual Presentation of Chronic Myeloid Leukemia as Retroperitoneal Hematoma: A Case Report 227 228 EN Yasir Bashir Fahim Manzoor Shuaeb Bhat Nusrat Bashir Department of Haematology, Sher -I -Kashmir Institute of Medical Sciences, Soura, Srinagar, Jammu and Kashmir, India Shabeer Ahmad Sajad Geelani Javid Rasool AJMCR20142108 10.12691/ajmcr-2-10-8 2014 09 26 2014 10 20 2014 10 24 Chronic myeloid leukemia(CML) usually remains asymptomatic and has varied clinical presentation. The disease usually has a chronic course till it goes into blast crisis when it develops fever, other constitutional symptoms and bleeding manifestations as seen in acute leukemia. Here, we present a case that came to our emergency department as a case of acute abdomen in the form of massive retroperitoneal hematoma and subsequently proved to be a case of Philadelphia positive CML with blast crisis.