Science and Education Publishing American Journal of Medical Case Reports ISSN Pending 2 1 2014 02 11 Aggressive Progression of Mantle Cell Lymphoma: A Case Report 30 31 EN Ilknur Nizam Department of Hematology, Faculty of Medicine, Inonu University, Malatya, Turkey Mehmet Ali Erkurt Ilhami Berber Emin Kaya Irfan Kuku Mustafa Koroglu AJMCR20142110 10.12691/ajmcr-2-1-10 2014 01 20 2014 01 23 2014 02 11 Mantle cell lymphoma is a relatively rare disease, mostly affecting the elderly. It behaves aggressively although it has features of an indolent lymphoma. Here, we presented a case of an 85-year old female patient applying to emergency service with difficulty in breathing due to huge lumps around her neck. She had mantle cell lymphoma which has aggressively progressed despite chemotherapy. She was at an advanced stage of the disease and taken to the intensive care unit. Despite best supportive care, steroid therapy and respiratory support, she passed away within 24 hours.