Dear Label_Name,

Greetings! I hope you are well.

I am writing on behalf of an international publishing house, Science and Education Publishing, USA (http://www.sciepub.com).

Science and Education Publishing (SciEP) is a multidisciplinary open access publisher of Journals covering the fields of Science, Technology and Medicine. All SciEP publications are subject to high-quality peer review, editorial and production processes and are freely available online.

Welcome to the April, 2013 edition of SciEP newsletter, providing monthly summaries of articles on science & education related topics of interest to scientist and professionals. The mission of our journals is to provide an open access forum for publishing new findings on issues pertinent to scientific and academic field. We also invite you to submit original research papers, review articles, short reports, or case studies are considered for publication in our Multidisciplinary Journals.

American Journal of Public Health Research
DOI: 10.12691/ajphr-1-1-3

The Implementation of a Tele-Homecare System with Service Oriented Architecture and HL7 Message Transmission Standard
Ching-Sung Wang

American Journal of Medical and Biological Research
DOI: 10.12691/ajmbr-1-1-2

The Influence of Ethanol on Pyruvate Kinases Activity in Vivo, in Vitro, in Silico
Lelevich Sergey Vladimirovich, Khrustalev Vladislav Victorovich, Barkovsky Eugene Victorovich, Shedogubova Tatyana Aleksandrovna

American Journal of Medical Sciences and Medicine
DOI: 10.12691/ajmsm-1-1-1

Clinical and Histological Features in Wegener Granulomatosis
Li Cavoli Gioacchino, Passantino Rita, Bono Luisa, Tortorici Calogera, Ferrantelli Angelo, Giammarresi Carlo, Rotolo Ugo

American Journal of Infectious Diseases and Microbiology
DOI: 10.12691/ajidm-1-1-2

The Curse of Lymphatic Filariasis: Would the Continual Use of Diethylcarbamazine Eliminate this Scourge in Papua New Guinea?
Anne Lanham, Lillian Mwanri

We have released issues of some journals on February 2013.
American Journal of Public Health Research
American Journal of Medical Sciences and Medicine
American Journal of Medical and Biological Research
American Journal of Pharmacological Sciences
American Journal of Clinical Medicine Research
American Journal of Nursing Research
American Journal of Cancer Prevention
American Journal of Medicine Studies
American Journal of Infectious Diseases and Microbiology
American Journal of Cardiovascular Disease Research
American Journal of Biomedical Research
American Journal of Mechanical Engineering
American Journal of Microbiological Research
Journal of Preventive Medicine
American Journal of Food and Nutrition
American Journal of Hypertension Research
American Journal of Sports Science and Medicine
Journal of Cancer Research and Treatment
American Journal of Zoological Research
Journal of Biomedical Engineering and Technology
American Journal of Microbiological Research
Biomedical Science and Engineering

We are pleased to announce that submissions are now being accepted for peer review for all the journals across all our subject areas in SciEP.

Please submit your manuscript via our online submission system:
http://www.sciepub.com/author/signin

To unsubscribe from our mailing list, please click on the following link: unsubscribe

I am looking forward to hearing from you.

Kind regards,

David Rain
Email:join@sciepub.com
Science and Education Publishing (http://www.sciepub.com)

Label_Title

Dear Label_Name,

Greetings! I hope you are well.

I am writing on behalf of an international publishing house, Science and Education Publishing, USA (http://www.sciepub.com).

Science and Education Publishing (SciEP) is a multidisciplinary open access publisher of Journals covering the fields of Science, Technology and Medicine. All SciEP publications are subject to high-quality peer review, editorial and production processes and are freely available online.

Welcome to the April, 2013 edition of SciEP newsletter, providing monthly summaries of articles on science & education related topics of interest to scientist and professionals. The mission of our journals is to provide an open access forum for publishing new findings on issues pertinent to scientific and academic field. We also invite you to submit original research papers, review articles, short reports, or case studies are considered for publication in our Multidisciplinary Journals.

American Journal of Public Health Research
DOI: 10.12691/ajphr-1-1-3

The Implementation of a Tele-Homecare System with Service Oriented Architecture and HL7 Message Transmission Standard
Ching-Sung Wang

American Journal of Medical and Biological Research
DOI: 10.12691/ajmbr-1-1-2

The Influence of Ethanol on Pyruvate Kinases Activity in Vivo, in Vitro, in Silico
Lelevich Sergey Vladimirovich, Khrustalev Vladislav Victorovich, Barkovsky Eugene Victorovich, Shedogubova Tatyana Aleksandrovna

American Journal of Medical Sciences and Medicine
DOI: 10.12691/ajmsm-1-1-1

Clinical and Histological Features in Wegener Granulomatosis
Li Cavoli Gioacchino, Passantino Rita, Bono Luisa, Tortorici Calogera, Ferrantelli Angelo, Giammarresi Carlo, Rotolo Ugo

American Journal of Infectious Diseases and Microbiology
DOI: 10.12691/ajidm-1-1-2

The Curse of Lymphatic Filariasis: Would the Continual Use of Diethylcarbamazine Eliminate this Scourge in Papua New Guinea?
Anne Lanham, Lillian Mwanri

We have released issues of some journals on February 2013.
American Journal of Public Health Research
American Journal of Medical Sciences and Medicine
American Journal of Medical and Biological Research
American Journal of Pharmacological Sciences
American Journal of Clinical Medicine Research
American Journal of Nursing Research
American Journal of Cancer Prevention
American Journal of Medicine Studies
American Journal of Infectious Diseases and Microbiology
American Journal of Cardiovascular Disease Research
American Journal of Biomedical Research
American Journal of Mechanical Engineering
American Journal of Microbiological Research
Journal of Preventive Medicine
American Journal of Food and Nutrition
American Journal of Hypertension Research
American Journal of Sports Science and Medicine
Journal of Cancer Research and Treatment
American Journal of Zoological Research
Journal of Biomedical Engineering and Technology
American Journal of Microbiological Research
Biomedical Science and Engineering

We are pleased to announce that submissions are now being accepted for peer review for all the journals across all our subject areas in SciEP.

Please submit your manuscript via our online submission system:
http://www.sciepub.com/author/signin

To unsubscribe from our mailing list, please click on the following link: unsubscribe

I am looking forward to hearing from you.

Kind regards,

David Rain
Email:join@sciepub.com
Science and Education Publishing (http://www.sciepub.com)

Label_Title

Dear Label_Name,

Greetings! I hope you are well.

I am writing on behalf of an international publishing house, Science and Education Publishing, USA (http://www.sciepub.com).

Science and Education Publishing (SciEP) is a multidisciplinary open access publisher of Journals covering the fields of Science, Technology and Medicine. All SciEP publications are subject to high-quality peer review, editorial and production processes and are freely available online.

Welcome to the April, 2013 edition of SciEP newsletter, providing monthly summaries of articles on science & education related topics of interest to scientist and professionals. The mission of our journals is to provide an open access forum for publishing new findings on issues pertinent to scientific and academic field. We also invite you to submit original research papers, review articles, short reports, or case studies are considered for publication in our Multidisciplinary Journals.

American Journal of Public Health Research
DOI: 10.12691/ajphr-1-1-3

The Implementation of a Tele-Homecare System with Service Oriented Architecture and HL7 Message Transmission Standard
Ching-Sung Wang

American Journal of Medical and Biological Research
DOI: 10.12691/ajmbr-1-1-2

The Influence of Ethanol on Pyruvate Kinases Activity in Vivo, in Vitro, in Silico
Lelevich Sergey Vladimirovich, Khrustalev Vladislav Victorovich, Barkovsky Eugene Victorovich, Shedogubova Tatyana Aleksandrovna

American Journal of Medical Sciences and Medicine
DOI: 10.12691/ajmsm-1-1-1

Clinical and Histological Features in Wegener Granulomatosis
Li Cavoli Gioacchino, Passantino Rita, Bono Luisa, Tortorici Calogera, Ferrantelli Angelo, Giammarresi Carlo, Rotolo Ugo

American Journal of Infectious Diseases and Microbiology
DOI: 10.12691/ajidm-1-1-2

The Curse of Lymphatic Filariasis: Would the Continual Use of Diethylcarbamazine Eliminate this Scourge in Papua New Guinea?
Anne Lanham, Lillian Mwanri

We have released issues of some journals on February 2013.
American Journal of Public Health Research
American Journal of Medical Sciences and Medicine
American Journal of Medical and Biological Research
American Journal of Pharmacological Sciences
American Journal of Clinical Medicine Research
American Journal of Nursing Research
American Journal of Cancer Prevention
American Journal of Medicine Studies
American Journal of Infectious Diseases and Microbiology
American Journal of Cardiovascular Disease Research
American Journal of Biomedical Research
American Journal of Mechanical Engineering
American Journal of Microbiological Research
Journal of Preventive Medicine
American Journal of Food and Nutrition
American Journal of Hypertension Research
American Journal of Sports Science and Medicine
Journal of Cancer Research and Treatment
American Journal of Zoological Research
Journal of Biomedical Engineering and Technology
American Journal of Microbiological Research
Biomedical Science and Engineering

We are pleased to announce that submissions are now being accepted for peer review for all the journals across all our subject areas in SciEP.

Please submit your manuscript via our online submission system:
http://www.sciepub.com/author/signin

To unsubscribe from our mailing list, please click on the following link: unsubscribe

I am looking forward to hearing from you.

Kind regards,

David Rain
Email:join@sciepub.com
Science and Education Publishing (http://www.sciepub.com)

Label_Title

Dear Label_Name,

Greetings! I hope you are well.

I am writing on behalf of an international publishing house, Science and Education Publishing, USA (http://www.sciepub.com).

Science and Education Publishing (SciEP) is a multidisciplinary open access publisher of Journals covering the fields of Science, Technology and Medicine. All SciEP publications are subject to high-quality peer review, editorial and production processes and are freely available online.

Welcome to the April, 2013 edition of SciEP newsletter, providing monthly summaries of articles on science & education related topics of interest to scientist and professionals. The mission of our journals is to provide an open access forum for publishing new findings on issues pertinent to scientific and academic field. We also invite you to submit original research papers, review articles, short reports, or case studies are considered for publication in our Multidisciplinary Journals.

American Journal of Public Health Research
DOI: 10.12691/ajphr-1-1-3

The Implementation of a Tele-Homecare System with Service Oriented Architecture and HL7 Message Transmission Standard
Ching-Sung Wang

American Journal of Medical and Biological Research
DOI: 10.12691/ajmbr-1-1-2

The Influence of Ethanol on Pyruvate Kinases Activity in Vivo, in Vitro, in Silico
Lelevich Sergey Vladimirovich, Khrustalev Vladislav Victorovich, Barkovsky Eugene Victorovich, Shedogubova Tatyana Aleksandrovna

American Journal of Medical Sciences and Medicine
DOI: 10.12691/ajmsm-1-1-1

Clinical and Histological Features in Wegener Granulomatosis
Li Cavoli Gioacchino, Passantino Rita, Bono Luisa, Tortorici Calogera, Ferrantelli Angelo, Giammarresi Carlo, Rotolo Ugo

American Journal of Infectious Diseases and Microbiology
DOI: 10.12691/ajidm-1-1-2

The Curse of Lymphatic Filariasis: Would the Continual Use of Diethylcarbamazine Eliminate this Scourge in Papua New Guinea?
Anne Lanham, Lillian Mwanri

We have released issues of some journals on February 2013.
American Journal of Public Health Research
American Journal of Medical Sciences and Medicine
American Journal of Medical and Biological Research
American Journal of Pharmacological Sciences
American Journal of Clinical Medicine Research
American Journal of Nursing Research
American Journal of Cancer Prevention
American Journal of Medicine Studies
American Journal of Infectious Diseases and Microbiology
American Journal of Cardiovascular Disease Research
American Journal of Biomedical Research
American Journal of Mechanical Engineering
American Journal of Microbiological Research
Journal of Preventive Medicine
American Journal of Food and Nutrition
American Journal of Hypertension Research
American Journal of Sports Science and Medicine
Journal of Cancer Research and Treatment
American Journal of Zoological Research
Journal of Biomedical Engineering and Technology
American Journal of Microbiological Research
Biomedical Science and Engineering

We are pleased to announce that submissions are now being accepted for peer review for all the journals across all our subject areas in SciEP.

Please submit your manuscript via our online submission system:
http://www.sciepub.com/author/signin

To unsubscribe from our mailing list, please click on the following link: unsubscribe

I am looking forward to hearing from you.

Kind regards,

David Rain
Email:join@sciepub.com
Science and Education Publishing (http://www.sciepub.com)

Cronkhite-Canada Syndrome: A Rare Presentation for Weight Loss, Diarrhea and Protein-Losing Enteropathy

Swetha Tummala*, Natalie Patel, Sanjeev Tummala

Department of Gastroenterology, Hepatology, and Nutrition, University of Pittsburgh Medical Center, Pittsburgh, USA

Abstract: Background: Cronkhite-Canada syndrome (CCS) is a rare, nonhereditary polyposis syndrome that causes protein-losing enteropathy, weight loss, diarrhea, and skin changes. Around 500 cases have been documented worldwide in 50 years. CCS is difficult to diagnose and many patients fail therapy and have high morbidity and mortality. We report CCS in a 62-year-old Asian male. Case Description: A 62-year-old healthy male presented with several weeks of bloating, loss of smell and taste, decreased appetite, diarrhea, darkened hands, and fingernail splitting () following a screening colonoscopy, which showed three small benign polyps. He also endorsed fifty pounds of weight loss over three months. Extensive investigation of infectious, neoplastic, and inflammatory causes was negative. Stool was positive for occult blood. He developed hypoproteinemia and markedly elevated calprotectin level to 4,260 μg/g. Endoscopy and repeat colonoscopy was performed with endoscopic ultrasound. This showed thickened polypoid folds in the stomach (), duodenum, and colon. Pathology revealed edematous lamina propria and cystically dilated glands throughout the gastrointestinal tract (). A diagnosis of CCS was made. The patient was started on prednisone plus mesalamine and a high-calorie, high-protein diet. In three months, he gained twenty pounds, and all of his symptoms improved. He continues to be followed by gastroenterology. Conclusions: CCS is rare. Most reported cases are from Asia. The etiology is unknown, but an autoimmune etiology has been purported due to positive responses to immunosuppression. Diagnosis combines clinical features of chronic diarrhea, weight loss, malnutrition, and skin changes with multiple hamartomatous polyps in the gastrointestinal tract. Management is primarily immunosuppression with glucocorticoids with or without 5-aminosalicylates. CCS can lead to complications, including infections and blood clots, and increased risk of gastrointestinal cancers. Nutritional support is crucial. Regular upper and lower endoscopies are important to monitor malignant complications. CCS is progressive with a poor prognosis. Given its rarity, prospective data on management is limited, and there are no guidelines for monitoring. This case shows how prompt diagnosis and multifaceted management for this rare syndrome can improve symptoms and disease control and encourages further studies to improve management.

Keywords: Cronkhite-Canada, polyposis, enteropathy

Received July 28, 2025; Revised August 30, 2025; Accepted September 07, 2025

Citation: Swetha Tummala, Natalie Patel, Sanjeev Tummala, Cronkhite-Canada Syndrome: A Rare Presentation for Weight Loss, Diarrhea and Protein-Losing Enteropathy. American Journal of Medical Case Reports, 13 (8). 46-49. January 2025. doi:10.12691/ajmcr-13-8-1

1. Introduction

Cronkhite-Canada syndrome (CCS) is a rare, nonhereditary polyposis syndrome that causes protein-losing enteropathy, chronic diarrhea, and dermatologic changes. Only around 500 cases have been documented worldwide, the majority from Japan [1]. CCS is difficult to diagnose, and many patients fail therapy and have high morbidity and mortality. We report CCS in a 62-year-old Asian male.

2. Case Presentation

A 62-year-old healthy male presented for a screening colonoscopy, which showed 3 small benign polyps. 1 day later, he started feeling bloated with loss of smell and taste and decreased appetite. COVID-19 rapid antigen test was negative. He saw his primary care physician who gave him simethicone and ordered labs. All labs were normal except stool was positive for occult blood. Subsequent endoscopy showed erythema from the stomach to the duodenum. Stomach biopsies showed edematous lamina propria with chronic gastritis. Biopsies were negative for H. pylori and metaplasia/dysplasia. Stains were negative for AFB. Immunostains were negative for gastrin and lymphoma. Duodenum biopsies showed edematous lamina propria, villous blunting, and eosinophilia. No definite diagnosis was possible. The patient was started on antacids and proton-pump inhibitors.

Over the next 2 months, the patient started losing weight and started to have fatigue and diarrhea. He was admitted for further workup. CT abdomen showed mild small bowel wall thickening. CT enterography was normal. MRI brain for his loss of smell/taste was normal. Abdominal ultrasound showed no gallstones. Labs showed elevated C-reactive protein level of 14.8 mg/L and calprotectin level of 4,260 μg/g. Albumin was low at 2.6 g/dl. Quantiferon test was positive but chest X-ray negative. Hep B surface antigen was positive with a virus load of 15,100 IU/ml. IgE was 641 KU/l (normal <114 KU/l). Gastrin level was 306 pg/ml (normal <100 pg/ml), but intrinsic factor and tests for parietal cell antibody were negative. IgG subclasses were normal. Other negative tests included: ova/parasite, CMV PCR, ANA, and respiratory virus panel. The patient was started on budesonide 9 mg daily. Within 1 month, his C-reactive protein level improved to 11.9 mg/L, and his calprotectin improved to 1,200 μg/g.

However, he continued to lose weight. At this point, 3 months into his illness, he had lost a total of 50 pounds. CCS, Menetrier disease, autoimmune gastroenteritis, and gastric cancer were on the differential. A repeat EGD/colonoscopy with EUS showed polypoid, thickened folds in the stomach, duodenum, and colon (Figure 1). Pathology revealed polypoid, edematous lamina propria and cystically dilated glands throughout the gastrointestinal tract (Figure 2, Figure 3). Around this time, the patient started experiencing darkening of the hands and fingernail splitting (Figure 4, Figure 5). Menetrier disease, autoimmune gastroenteritis, and gastric cancer lack skin findings and diffuse involvement of the gastrointestinal tract. Based on these clinical features and endoscopy and pathology findings, the patient was diagnosed with CCS.

Figure 1. Images obtained during endoscopy show thickened polypoid folds with edema and inflammation in the stomach, duodenum, and ascending to transverse colon

Figure 2. On hematoxylin and eosin staining, a resection specimen from the stomach shows polypoid architecture, cystically dilated glands, and edematous lamina propria at low magnification (A) and high magnification (B)

Figure 3. On hematoxylin and eosin staining, a resection specimen from the colon shows polypoid architecture, cystically dilated glands, and edematous lamina propria at low magnification (A) and high magnification (B)

Figure 4. Darkened hands

Figure 5. Fingernail splitting

Budesonide was stopped. The patient was started on prednisone 40 mg plus mesalamine 1.2 g daily, and tenofovir 300 mg daily for chronic hepatitis B. He was referred to a dietician, who started him on a high-calorie, high-protein diet with daily Peptamen supplementation. Within three months, he gained thirty pounds, all his symptoms improved, and his C-reactive protein level normalized. He continues to be followed by gastroenterology and infectious disease.

3. Discussion

Since CCS was first documented in 1955 [2,3], only around 500 cases have been documented worldwide, 75% of which are from Japan. The etiology of CCS is unknown, but it is thought to be autoimmune-related given positive autoimmune markers, increased IgG4 levels, and positive responses to immunosuppression [4].

There is no diagnostic criteria for CCS. Diagnosis combines clinical features with hamartomatous polyps in the gastrointestinal tract. Diarrhea is the most common symptom (80%) [5,6]. Patients also often present with malnutrition. Dermatological changes include hyperpigmentation and onychodystrophy. Gastrointestinal polyps in CCS are largely hamartomatous. However, cases have been documented of malignant polyps and serrated polyps becoming colorectal cancer. Histological features of CCS polyps include cystically dilated glands and lamina propria edema. However, these are non-specific.

CCS is progressive and has a poor prognosis with a 5-year mortality of 55%, largely due to complications of sepsis, gastrointestinal bleeding, malnourishment, electrolyte imbalances, and malignancy. Complete remission has only been documented in 5% of cases [7,8].

Prospective data on management is limited given the rarity of CCS. Most management is guided by case reports and series. The mainstay of medical management is immunosuppression with glucocorticoids. Case series and retrospective cohort studies showed that over half of patients on glucocorticoids for CCS had symptom reductions and polyp regression [9,10]. Some of these patients were additionally on a 5-aminosalicylate, which have been shown to have an antiproliferative effect on colorectal adenomas [11]. However, there is no consensus on glucocorticoid type, route, dose, duration, or need for maintenance therapy. Multicenter collaborations are needed to develop treatment guidelines for rare diseases like CCS.

Patients who are refractory to glucocorticoids can receive immunosuppressants like azathioprine, cyclosporine, or infliximab [12,13]. Medical management also includes treating H.pylori infection and gastroesophageal reflux disease. Surgery is reserved for patients with refractory CCS or malignant complications.

CCS can lead to complications. CCS leads to increased infection risk due to immunosuppressants and the loss of immunoglobulins from protein-losing enteropathy. CCS leads to increased risk of deep vein thrombosis and pulmonary embolism due to the loss of anticoagulation factors from protein-losing enteropathy. Therefore, prophylactic anticoagulation must be considered. There is also increased risk of gastrointestinal bleeding due to frequent surveillance endoscopies.

Lastly, nutritional support and electrolyte replacement are crucial. If enteral feeding is not tolerated or nutritional deficiencies are refractory to enteral feeding, parenteral nutrition must be considered.

There are no guidelines for monitoring treatment. Regular upper and lower endoscopies are important to monitor polyposis and malignant complications. Improvements in symptoms, albumin, and electrolytes can warrant de-escalation of nutritional support and electrolyte replacement.

4. Conclusion

CCS is a rare, nonhereditary polyposis syndrome that causes protein-losing enteropathy, chronic diarrhea, and dermatologic changes. Given the rarity, there is no diagnosis criteria, and prospective data on management is limited. This case shows how prompt diagnosis and multifaceted management, including glucocorticoid therapy and nutritional support can improve symptoms and disease control. We hope this case encourages more prospective studies and multicenter collaborations to better define treatment pathways for CCS.

ACKNOWLEDGEMENTS

Thank you to the University of Pittsburgh Medical Center, Peninsula Pathologists Medical Group, and the Palo Alto Medical Foundation.

References

[1]   | Goto A. Cronkhite-Canada Syndrome: Epidemiological study of 110 cases reported in Japan. Nippon Geka Hokan. 1995; 64(1): 3-14.
[2]   | Cronkhite LW Jr, Canada WJ. Generalized gastrointestinal polyposis; an unusual syndrome of polyposis, pigmentation, alopecia and onychotrophia. N Engl J Med. 1955; 252(24): 1011–5.
[3]   | Gardner EJ, Burt RW, Freston JW. Gastrointestinal polyposis: Syndromes and genetic mechanisms. West J Med. 1980; 132: 488–499.
[4]   | Sweetser S, Ahlquist DA, Osborn NK, Sanderson SO, Smyrk TC, Chari ST, Boardman LA. Clinicopathologic features and treatment outcomes in Cronkhite-Canada syndrome: support for autoimmunity. Dig Dis Sci. 2012; 57(2): 496–502.
[5]   | Ward EM, Wolfsen HC. Review article: The non-inherited gastrointestinal polyposis syndromes. Aliment Pharmacol Ther. 2002; 16: 333–342.
[6]   | Daniel ES, Ludwig SL, Lewin KJ, Ruprecht RM, Rajacich GM, Schwabe AD. The Cronkhite-Canada syndrome. An analysis of clinical and pathologic features and therapy in 55 patients. Medicine (Baltimore). 1982; 61(5): 293–309.
[7]   | Chadalavada R, Brown DK, Walker AN, Sedghi S. Cronkhite-Canada syndrome: sustained remission after corticosteroid treatment. Am J Gastroenterol. 2003; 98: 1444–1446.
[8]   | Dore MP, Satta R, Murino A, Pes GM. Long-lasting remission in a case of Cronkhite-Canada syndrome. BMJ Case Rep. 2018: bcr-2017-223527.
[9]   | Peart AG Jr, Sivak MV Jr, Rankin GB, Kish LS, Steck WD. Spontaneous improvement of Cronkhite-Canada syndrome in a postpartum female. Dig Dis Sci. 1984; 29(5): 470–4.
[10]   | Takakura MAH, Tsuchihashi N, Miyazaki E, Yoshioka Y, Yoshida K, Oryo F, Sawada T. A case of cronkhite-Canada syndrome markedly improved with mesalazine therapy. Dig Endosc. 2004; 16: 74–8.
[11]   | Schulte, S., Kütting, F., Mertens, J. et al. Case report of patient with a Cronkhite-Canada syndrome: sustained remission after treatment with corticosteroids and mesalazine. BMC Gastroenterol. 2019; 19(1): 36.
[12]   | Yamakawa K, Yoshino T, Watanabe K, Kawano K, Kurita A, Matsuzaki N, et al Effectiveness of cyclosporine as a treatment for steroid-resistant Cronkhite-Canada syndrome; two case reports. BMC Gastroenterol. 2016; 16(1): 123.
[13]   | Jiang CD, Myint H, Tie A, Stace NH. Sustained clinical response to infliximab in refractory Cronkhite-Canada syndrome. BMJ Case Rep. 2020; 13(12).