@article{ajmcr20251371,
author={{Villegas, Jorge L¨®pez and Altamirano, Leonardo Granados and Rodr¨ªguez, Jos¨¦ Rojas and Mena, Betzab¨¦ Rojas},
title={Myeloid Sarcoma with a PICALM¨CMLLT10 Fusion Presenting as an Isolated Mediastinal Mass in a Middle-Aged Asian Male: A Case Report},
journal={American Journal of Medical Case Reports},
volume={13},
number={7},
pages={37--40},
year={2025},
url={https://pubs.sciepub.com/ajmcr/13/7/1},
issn={2374-216X},
abstract={Myeloid sarcoma (MS), also known as granulocytic sarcoma or chloroma, is a rare extramedullary manifestation of acute myeloid leukemia (AML). Mediastinal presentation is exceedingly uncommon and may lead to misdiagnosis, particularly when hematologic parameters are preserved. We report the case of a 44-year-old male who presented with constitutional symptoms and an isolated anterior mediastinal mass without peripheral blood abnormalities. Diagnosis was established through flow cytometry, histopathology, and immunohistochemistry. Molecular profiling revealed a complex mutational landscape including <i>PHF6</i>, <i>TP53</i>, <i>WT1</i> mutations, and a <i>PICALM¨CMLLT10</i> fusion. The patient was treated with AML-directed chemotherapy and remains under close surveillance. This case highlights the diagnostic challenges and prognostic implications of extramedullary AML with rare genetic alterations.},
doi={10.12691/ajmcr-13-7-1}
publisher={Science and Education Publishing}
}