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American Journal of Public Health Research
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The Implementation of a Tele-Homecare System with Service Oriented Architecture and HL7 Message Transmission Standard
Ching-Sung Wang

American Journal of Medical and Biological Research
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The Influence of Ethanol on Pyruvate Kinases Activity in Vivo, in Vitro, in Silico
Lelevich Sergey Vladimirovich, Khrustalev Vladislav Victorovich, Barkovsky Eugene Victorovich, Shedogubova Tatyana Aleksandrovna

American Journal of Medical Sciences and Medicine
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Clinical and Histological Features in Wegener Granulomatosis
Li Cavoli Gioacchino, Passantino Rita, Bono Luisa, Tortorici Calogera, Ferrantelli Angelo, Giammarresi Carlo, Rotolo Ugo

American Journal of Infectious Diseases and Microbiology
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The Curse of Lymphatic Filariasis: Would the Continual Use of Diethylcarbamazine Eliminate this Scourge in Papua New Guinea?
Anne Lanham, Lillian Mwanri

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Dear Label_Name,

Greetings! I hope you are well.

I am writing on behalf of an international publishing house, Science and Education Publishing, USA (http://www.sciepub.com).

Science and Education Publishing (SciEP) is a multidisciplinary open access publisher of Journals covering the fields of Science, Technology and Medicine. All SciEP publications are subject to high-quality peer review, editorial and production processes and are freely available online.

Welcome to the April, 2013 edition of SciEP newsletter, providing monthly summaries of articles on science & education related topics of interest to scientist and professionals. The mission of our journals is to provide an open access forum for publishing new findings on issues pertinent to scientific and academic field. We also invite you to submit original research papers, review articles, short reports, or case studies are considered for publication in our Multidisciplinary Journals.

American Journal of Public Health Research
DOI: 10.12691/ajphr-1-1-3

The Implementation of a Tele-Homecare System with Service Oriented Architecture and HL7 Message Transmission Standard
Ching-Sung Wang

American Journal of Medical and Biological Research
DOI: 10.12691/ajmbr-1-1-2

The Influence of Ethanol on Pyruvate Kinases Activity in Vivo, in Vitro, in Silico
Lelevich Sergey Vladimirovich, Khrustalev Vladislav Victorovich, Barkovsky Eugene Victorovich, Shedogubova Tatyana Aleksandrovna

American Journal of Medical Sciences and Medicine
DOI: 10.12691/ajmsm-1-1-1

Clinical and Histological Features in Wegener Granulomatosis
Li Cavoli Gioacchino, Passantino Rita, Bono Luisa, Tortorici Calogera, Ferrantelli Angelo, Giammarresi Carlo, Rotolo Ugo

American Journal of Infectious Diseases and Microbiology
DOI: 10.12691/ajidm-1-1-2

The Curse of Lymphatic Filariasis: Would the Continual Use of Diethylcarbamazine Eliminate this Scourge in Papua New Guinea?
Anne Lanham, Lillian Mwanri

We have released issues of some journals on February 2013.
American Journal of Public Health Research
American Journal of Medical Sciences and Medicine
American Journal of Medical and Biological Research
American Journal of Pharmacological Sciences
American Journal of Clinical Medicine Research
American Journal of Nursing Research
American Journal of Cancer Prevention
American Journal of Medicine Studies
American Journal of Infectious Diseases and Microbiology
American Journal of Cardiovascular Disease Research
American Journal of Biomedical Research
American Journal of Mechanical Engineering
American Journal of Microbiological Research
Journal of Preventive Medicine
American Journal of Food and Nutrition
American Journal of Hypertension Research
American Journal of Sports Science and Medicine
Journal of Cancer Research and Treatment
American Journal of Zoological Research
Journal of Biomedical Engineering and Technology
American Journal of Microbiological Research
Biomedical Science and Engineering

We are pleased to announce that submissions are now being accepted for peer review for all the journals across all our subject areas in SciEP.

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A Case of Adult Survival Following Multidisciplinary Treatment Including Venovenous Extracorporeal Membrane Oxygenation (VV-ECMO) for Severe Mycoplasma Pneumonia

Ayaka Tashiro, Raiki Tokutsu, Youichi Yanagawa*

Department of Acute Critical Care Medicine, Shizuoka Hospital, Juntendo University

Abstract: A 58-year-old male with a history of smoking presented to a local hospital with cough and dyspnea for one week. He was transferred to our hospital due to decreased right lung transparency and impaired oxygenation. Upon arrival, his PaO2/FiO2 ratio was approximately 70, necessitating intubation and mechanical ventilation. Levofloxacin was initiated due to a positive Mycoplasma antigen test. After admission to the intensive care unit, steroid pulse therapy was also initiated. However, oxygenation and ventilation deteriorated further. It was determined that mechanical ventilation alone could not sustain life, leading to the initiation of venovenous extracorporeal membrane oxygenation (VV-ECMO) on the second day of hospitalization. Subsequently, oxygenation and ventilation showed a trend of improvement. Due to bleeding from the cannula insertion site, the ECMO was weaned off on the fifth day. Respiratory status subsequently stabilized, leading to extubation on the seventh day of illness. Oxygen requirements ceased, and the patient was discharged home walking unaided on the thirty-third day of illness. This case demonstrates the value of using ECMO when indications are met and it is determined that mechanical ventilation alone is unlikely to sustain life in severe Mycoplasma pneumonia.

Keywords: mycoplasma pneumonia, ECMO, steroid

Received October 20, 2025; Revised November 24, 2025; Accepted December 01, 2025

Citation: Ayaka Tashiro, Raiki Tokutsu, Youichi Yanagawa, A Case of Adult Survival Following Multidisciplinary Treatment Including Venovenous Extracorporeal Membrane Oxygenation (VV-ECMO) for Severe Mycoplasma Pneumonia. American Journal of Medical Case Reports, 13 (11). 79-83. January 2025. doi:10.12691/ajmcr-13-11-4

1. Introduction

Most cases of Mycoplasma infection are limited to a single organ and present with only mild systemic symptoms, allowing for full recovery after treatment and generally favorable outcomes. However, reinfection can occur.1,2 In rare cases, fulminant or fatal disease caused by Mycoplasma pneumoniae has been reported, often associated with complications or severe systemic involvement leading to multiple organ failure. [1,2,3,4] Fulminant cases of Mycoplasma pneumonia are estimated to account for 0.2–0.5% of all cases. [1] Severe manifestations are most commonly observed in children and young adults. [3,4,5] Herein, we report an adult case of severe Mycoplasma pneumonia requiring multidisciplinary treatment, including mechanical ventilation and veno-venous extracorporeal membrane oxygenation (VV-ECMO).

2. Case Report

A 58-year-old man with a history of smoking presented to a local clinic with a one-week history of cough and dyspnea. Chest radiography revealed decreased transparency in the right lung, and hypoxemia was also noted. He was transferred to our hospital. On arrival, he exhibited tachycardia and tachypnea with poor oxygenation, necessitating tracheal intubation and mechanical ventilation. Chest computed tomography demonstrated right lung-dominant infiltrates (Figure 1). Laboratory tests revealed a white blood cell count of 12,400/μL (neutrophils 71.2%, monocytes 19.2%, lymphocytes 8.4%) without a left shift, suggesting atypical pneumonia. A rapid diagnostic test was positive for Mycoplasma antigen, and the patient was diagnosed with Mycoplasma pneumoniae pneumonia. Treatment with levofloxacin and steroid pulse therapy was initiated. Despite intensive care unit (ICU) management, oxygenation and ventilation remained inadequate, and progressive respiratory acidosis due to CO₂ retention developed on the following day. Therefore, venovenous extracorporeal membrane oxygenation (VV-ECMO) was initiated. After initiation, oxygenation and radiographic lung transparency showed gradual improvement. However, persistent bleeding from the cannulation site increased transfusion requirements. Although the patient’s P/F ratio remained approximately 130, which did not meet the standard criteria for weaning, VV-ECMO was discontinued on hospital day 5. Because of signs of heart failure, diuretics were administered. Steroid therapy was gradually tapered over one month to prevent the progression to pulmonary fibrosis. The patient’s respiratory condition subsequently stabilized, and he was extubated on hospital day 7. Oxygen supplementation was no longer required, and he was discharged home ambulatory on hospital day 33.

Figure 1. Chest computed tomography (CT) at admission

The CT revealed infiltrates predominantly in the right lung.

3. Discussion

This case involved a patient with Mycoplasma pneumonia who developed severe disease but improved following multidisciplinary treatment including ECMO. A literature search was conducted using the keywords Mycoplasma and either ECMO or PCPS, which yielded 23 reports comprising 42 cases (Table 1). [6,7,8,9,10] [11,12,13,14,15] [16,17,18,19,20] [21,22,23,24,25] [26,27,28] The ages of the patients ranged from 1 to 67 years (mean, 13.4 years), with most cases involving children or adolescents. Regarding sex distribution, excluding one case reported by Masuda et al. in which the sex was not specified, 18 of 23 cases were female, indicating a slight female predominance. As for outcomes, excluding the nine cases reported by Zhou et al. in which the prognosis after ECMO initiation was not described, the mortality rate was 7 of 33 cases (21.2%). The oldest patient was 67 years old, and this case resulted in death. In terms of age among reported ECMO cases, the present patient represents the second oldest, following a 67-year-old patient. As the 67-year-old case resulted in death, the present case is the oldest patient to be successfully treated with ECMO.

Most cases of Mycoplasma pneumonia that progress to severe pneumonia occur in young individuals (Table 1). This is thought to be due to the absence of prior infection with Mycoplasma, together with immature immune function and insufficient acquired immunity during childhood. 4 In contrast, elderly individuals may also develop severe Mycoplasma pneumonia. Possible explanations include the presence of multiple Mycoplasma species, the possibility of infection with different strains, and attenuation of previously acquired active immunity due to age-related decline in immune function or comorbidities. [1,30,31,32] In the present case, the patient was 58 years old, and factors such as age-related immunosenescence and a history of smoking—which can lead to altered ciliary motility, increased nasopharyngeal carriage of organisms, impaired alveolar macrophage function, and increased epithelial permeability—may have contributed to both susceptibility to Mycoplasma infection and progression to severe disease. [33,34]

Delay in diagnosis has also been considered a contributing factor to disease severity. In the present case, however, severe pneumonia without a left shift of leukocytes led us to suspect atypical pneumonia. Prompt diagnostic testing allowed us to establish the diagnosis of Mycoplasma pneumonia on the same day and initiate levofloxacin therapy, which may have contributed to survival. Furthermore, disease progression in severe Mycoplasma pneumonia is thought to be associated with a delayed-type hypersensitivity reaction to Mycoplasma, and reports have demonstrated lower mortality in patients treated with corticosteroids, which suppress this response. In this case as well, the use of steroid pulse therapy followed by a tapering regimen over the course of one month may have played an important role in the favorable outcome. [3]

The ECMO is a life-support modality for adults and children with life-threatening cardiac and respiratory failure who are unresponsive to conventional therapies, including cardiopulmonary resuscitation. [35] The ECMO circuit consists of a pump and an oxygenator, providing temporary cardiopulmonary support and allowing time for organ recovery. [35] A review of previous reports of severe pneumonia caused by Mycoplasma pneumoniae (Table 1) indicates that approximately 80% of cases were successfully rescued with ECMO, suggesting that ECMO demonstrates a certain degree of efficacy in severe Mycoplasma pneumonia. While the tendency of Mycoplasma pneumoniae infection to progress to severe disease in children and young adults is likely reflected in the age distribution of ECMO-treated cases, the relatively higher proportion of younger patients may also be due to the more restricted indications for ECMO in the elderly. With an aging society, the incidence of severe Mycoplasma pneumonia in elderly patients with declining immune function is expected to increase. This case highlights that even in elderly patients, if the indications for ECMO are met and mechanical ventilation alone is considered insufficient for survival, the use of ECMO can be justified.

Table 1. Review of Previous Reports on the Use of ECMO for Mycoplasma pneumoniae Pneumonia

4. Conclusion

This case represents the oldest surviving patient with severe Mycoplasma pneumonia who was treated with ECMO. This case demonstrates that in elderly patients as well, when the indications for ECMO are met and survival is unlikely with mechanical ventilation alone, the introduction of ECMO can be a reasonable treatment option.

ACKNOWLEDGEMENTS

This work was supported in part by a Grant-in-Aid for Special Research in Subsidies for ordinary expenses of private schools from The Promotion and Mutual Aid Corporation for Private Schools of Japan.

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