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The Implementation of a Tele-Homecare System with Service Oriented Architecture and HL7 Message Transmission Standard
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The Influence of Ethanol on Pyruvate Kinases Activity in Vivo, in Vitro, in Silico
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American Journal of Medical Sciences and Medicine
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Clinical and Histological Features in Wegener Granulomatosis
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American Journal of Infectious Diseases and Microbiology
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Anne Lanham, Lillian Mwanri

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Dear Label_Name,

Greetings! I hope you are well.

I am writing on behalf of an international publishing house, Science and Education Publishing, USA (http://www.sciepub.com).

Science and Education Publishing (SciEP) is a multidisciplinary open access publisher of Journals covering the fields of Science, Technology and Medicine. All SciEP publications are subject to high-quality peer review, editorial and production processes and are freely available online.

Welcome to the April, 2013 edition of SciEP newsletter, providing monthly summaries of articles on science & education related topics of interest to scientist and professionals. The mission of our journals is to provide an open access forum for publishing new findings on issues pertinent to scientific and academic field. We also invite you to submit original research papers, review articles, short reports, or case studies are considered for publication in our Multidisciplinary Journals.

American Journal of Public Health Research
DOI: 10.12691/ajphr-1-1-3

The Implementation of a Tele-Homecare System with Service Oriented Architecture and HL7 Message Transmission Standard
Ching-Sung Wang

American Journal of Medical and Biological Research
DOI: 10.12691/ajmbr-1-1-2

The Influence of Ethanol on Pyruvate Kinases Activity in Vivo, in Vitro, in Silico
Lelevich Sergey Vladimirovich, Khrustalev Vladislav Victorovich, Barkovsky Eugene Victorovich, Shedogubova Tatyana Aleksandrovna

American Journal of Medical Sciences and Medicine
DOI: 10.12691/ajmsm-1-1-1

Clinical and Histological Features in Wegener Granulomatosis
Li Cavoli Gioacchino, Passantino Rita, Bono Luisa, Tortorici Calogera, Ferrantelli Angelo, Giammarresi Carlo, Rotolo Ugo

American Journal of Infectious Diseases and Microbiology
DOI: 10.12691/ajidm-1-1-2

The Curse of Lymphatic Filariasis: Would the Continual Use of Diethylcarbamazine Eliminate this Scourge in Papua New Guinea?
Anne Lanham, Lillian Mwanri

We have released issues of some journals on February 2013.
American Journal of Public Health Research
American Journal of Medical Sciences and Medicine
American Journal of Medical and Biological Research
American Journal of Pharmacological Sciences
American Journal of Clinical Medicine Research
American Journal of Nursing Research
American Journal of Cancer Prevention
American Journal of Medicine Studies
American Journal of Infectious Diseases and Microbiology
American Journal of Cardiovascular Disease Research
American Journal of Biomedical Research
American Journal of Mechanical Engineering
American Journal of Microbiological Research
Journal of Preventive Medicine
American Journal of Food and Nutrition
American Journal of Hypertension Research
American Journal of Sports Science and Medicine
Journal of Cancer Research and Treatment
American Journal of Zoological Research
Journal of Biomedical Engineering and Technology
American Journal of Microbiological Research
Biomedical Science and Engineering

We are pleased to announce that submissions are now being accepted for peer review for all the journals across all our subject areas in SciEP.

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Bilateral Wilms’ Tumor: Challenges in Pediatric Nephron-Sparing Strategies and Multimodal Management

Salma Alhajj Qasem*, Adil A. A. Alsweis, Samer Bustame, Amna Akkawi

Department of Medicine, An-Najah National University, PO Box 7, Nablus, West Bank, Palestine

Abstract: Abstract Wilms' tumor, or nephroblastoma, is a rare pediatric kidney cancer that poses significant challenges, particularly in bilateral cases where preserving kidney function is critical. A 3-year-old girl presented with tumors in both kidneys, detected via ultrasonography and further evaluated with computed tomography (CT), revealing masses measuring 9.5 × 10 × 11 cm in the right kidney and 10 × 11 × 13.5 cm in the left. After ten weeks of chemotherapy with vincristine, dactinomycin, and doxorubicin, she underwent laparoscopic partial nephrectomy of the left kidney and excision of three tumors from the right-—histopathological analysis confirmed stage 5 intermediate-risk Wilms' tumor. Postoperatively, systemic adjuvant chemotherapy was administered, and routine follow-up evaluations confirmed no tumor recurrence and stable kidney function. This case underscores the complexity of treating bilateral Wilms' tumor and highlights the need for a delicate balance between aggressive oncologic treatment and the preservation of essential organ function.

Keywords: Wilms’ tumor, Nephron-sparing surgery (NSS), Pediatric nephrectomy

Received September 23, 2025; Revised October 25, 2025; Accepted November 02, 2025

Citation: Salma Alhajj Qasem, Adil A. A. Alsweis, Samer Bustame, Amna Akkawi, Bilateral Wilms’ Tumor: Challenges in Pediatric Nephron-Sparing Strategies and Multimodal Management. American Journal of Medical Case Reports, 13 (10). 59-62. January 2025. doi:10.12691/ajmcr-13-10-1

1. Introduction

Wilms' tumor, or nephroblastoma, is the most common renal malignancy in children, accounting for nearly 90% of pediatric kidney cancers [1]. It primarily affects children aged two to five years and is rare after the age of ten [3]. There is a slight female predominance [4]. Approximately 10% of cases are bilateral or multifocal, often presenting at a younger age [5,6]. The classic presentation involves an abdominal mass that may be discovered incidentally or through symptoms such as hematuria, abdominal pain, or hypertension in about 25% of cases [7]. Ultrasonography is the initial diagnostic tool, followed by CT or MRI to assess tumor extent and potential metastases, most commonly to the lungs or liver [8,9]. For unilateral tumors, radical nephrectomy followed by adjuvant chemotherapy is standard, achieving over 90% survival for localized disease [11,12,13]. In contrast, bilateral Wilms' tumor requires a more conservative approach to preserve renal tissue. Neoadjuvant chemotherapy is usually administered to shrink the tumors before surgery, followed by nephron-sparing surgery (NSS) whenever possible [12,14]. This report describes a rare case of large, bilateral Wilms' tumors managed successfully with single-stage bilateral NSS after neoadjuvant chemotherapy, illustrating the surgical and oncologic strategies required to achieve optimal outcomes.

2. Case Presentation

The patient was a 3-year-old girl with no significant medical or surgical history and an unremarkable prenatal and neonatal history who achieved all her developmental milestones appropriately. She started experiencing constant abdominal pain for three weeks before presenting to the hospital. The pain was intermittent and minimally relieved with traditional treatment. One week before admission to the hospital, her family noticed that her abdomen had become more distended and sought medical advice; she was admitted to the hospital. Abdominal ultrasonography revealed bilateral renal masses. Further investigation was performed, including a CT scan of the abdomen, which showed asymmetrical large masses in both kidneys using oral and intravenous contrast. Results showed several masses in the right kidney, with the largest one measuring 9.5 x 10 x 11 cm, causing a significant mass effect on the liver. The larger mass in the left kidney measured 10 x 11 x 13.5 cm, pushing against nearby bowel structures, touching the end of the pancreas, and putting pressure on the rest of the kidney. Necrosis was present in the masses; however, no calcification was detected. There was no inferior vena cava invasion, and both renal veins were patent. Laboratory evaluation revealed a creatinine level of 0.27 mg/dL. Figure 1

Figure 1. A coronal CT image demonstrates a large, heterogeneous, lobulated soft tissue lesion originating from the upper and mid poles of the left kidney, with areas of variable attenuation. The right kidney also shows similar lesions, indicating multifocal and bilateral renal involvement

The patient underwent a ten-week chemotherapy regimen with vincristine, dactinomycin, and doxorubicin. An abdominal computed tomography (CT) scan was then performed, revealing a significant reduction in the size of the tumors in both the left and right kidneys (10 × 11 × 13.5 cm to 5 × 5 × 4.5 cm and 9.5 × 10 × 13 cm to 5.5 × 5 × 7 cm, respectively) Figure 2.

Figure 2. Axial CT scans showing bilateral renal masses before chemotherapy (left), with clear lesions in both kidneys, and after chemotherapy (right), with the tumors getting much smaller

The patient underwent nephron-sparing surgery (NSS) despite significant tumor size following the completion of chemotherapy. The procedure began with inserting a 10 Fr Foley catheter after releasing labial fusion. A 7 cm transverse incision was made on the left side, approximately 2 cm below the costal margin. The incision was carefully deepened layer by layer until the retroperitoneum was reached, where the left kidney was encountered. A mass was identified at the medial superior pole of the kidney, and a partial nephrectomy was performed using electrocautery to remove the tumor while preserving the renal artery and vein. Due to the tumor's proximity, partial resection of the suprarenal gland was also required. The resection site was secured. Attention was then directed to the right side, where a 6 cm skin incision was made 2 cm below the costal margin. The peritoneum was carefully entered, exposing the right kidney. Three palpable hard masses were meticulously resected. During the procedure, an inadvertent opening of the right renal pelvic calyceal system occurred, necessitating the insertion of a 4.18 Double-J stent and subsequent closure. The renal artery, vein, and part of the right suprarenal gland were preserved. The kidney border was approximated. Examination of the bowel and mesentery confirmed their integrity. Hemostasis was achieved, and two Biovac drains were placed—one in the right and one in the left gutter. The surgical wounds were closed in two layers, with skin edges approximated in a subcuticular fashion. Postoperatively, the Foley catheter was replaced with a 12 Fr catheter.

Histopathological analysis confirmed a Wilms tumor of intermediate risk, classified as International Society of Pediatric Oncology (SIOP) stage 5. Following initial pediatric intensive care unit monitoring, the patient was transferred to the ward and discharged in good general condition within 10 days. A postoperative CT scan confirmed normal kidney anatomy with no signs of hydronephrosis Figure 3. Her creatinine was 0.41 mg/dL immediately after surgery and decreased to 0.26 mg/dL after 10 days, indicating preserved kidney function. The patient then commenced Stage II high-risk chemotherapy, consisting of four cycles over 13 weeks. Follow-up tests showed that the tumor had gone entirely, and the kidneys were still functioning properly.

Figure 3. An axial CT scan of the abdomen and pelvis shows that both kidneys are normal, and there is no sign of hydronephrosis (blue arrows). Red arrows indicate the expected locations of post-surgical clips (red arrows)

3. Discussion

Wilms' tumor represents the most common renal malignancy in children, with bilateral or multifocal cases comprising approximately 10% [5,6]. The management of bilateral Wilms' tumor is particularly challenging, as it demands a careful balance between achieving complete tumor resection and preserving renal function. While staged or sequential NSS has been more commonly reported, successful single-stage bilateral NSS for large tumors remains rare. Previous studies have reported limited numbers of such cases, often favoring two-stage approaches to minimize ischemic time and surgical complexity [17]. Our case demonstrates that with adequate tumor shrinkage after neoadjuvant chemotherapy, single-stage bilateral NSS can be safely performed with excellent renal and oncologic outcomes.

Genetic predispositions, including WT1 and WT2 mutations, play roles in bilateral disease development [15,16]; however, our patient had no syndromic or familial risk factors. Intraoperative challenges, such as right renal pelvic injury managed with stent placement, emphasize the need for readiness to address complications while maintaining renal viability.

From a surgical planning perspective, multidisciplinary coordination is critical—preoperative imaging guides safe resection planes, and intraoperative precision ensures vascular preservation. Postoperative care should focus on renal monitoring and prevention of chemotherapy-related late effects such as cardiotoxicity or chronic kidney disease [18,19,20].

This case provides valuable insights: (1) single-stage bilateral NSS can be feasible in well-selected patients after adequate tumor downstaging, (2) careful surgical technique enables kidney preservation even in complex anatomy, and (3) long-term follow-up is essential to monitor renal and oncologic outcomes.

Upon presentation, the patient had large, asymmetrical bilateral tumors, both of which were displacing adjacent structures like the pancreas, bowel, and liver, without involvement of the inferior vena cava (IVC). Nephron-sparing surgery (NSS) is typically the standard of care for bilateral Wilms' tumor and can be performed as either a one- or two-stage procedure. Some medical practices recommend starting with neoadjuvant chemotherapy before surgery, followed by surgical tumor resection and postoperative chemotherapy or radiotherapy [17]. For this patient, chemotherapy was initiated after diagnosis, followed by a one-stage surgery despite the challenging size and location of the tumors near critical structures. The surgical resection preserved the function of both kidneys. Follow-up over the next year showed no deterioration in kidney function or recurrence, suggesting the success of this aggressive but nephron-sparing approach. An intraoperative complication occurred when the renal pelvis on the right side was inadvertently opened, requiring the placement of a Double-J stent, a rare issue in such cases.

With improved survival rates for Wilms' tumor, the focus has shifted to manage late complications resulting from treatment. Chemotherapy that includes doxorubicin carries the risk of developing congestive heart failure [18], and other late complications include secondary cancers due to chemotherapy or radiation therapy [9]. Chronic kidney disease is another significant concern, particularly for patients with bilateral Wilms' tumor, with approximately 12% of patients developing end-stage renal disease [19]. While this can also occur in survivors of non-syndromic unilateral Wilms' tumor, it is less common. Given these risks, long-term follow-up is essential to monitor for potential renal complications later in life [20].

This case highlights that single-stage nephron-sparing surgery is a feasible option for large bilateral Wilms' tumors when tumor shrinkage allows for safe surgical margins. Additionally, the successful management of renal pelvic injury during surgery, without compromising renal function, provides valuable insights that may guide future nephron-sparing protocols.

4. Conclusion

This case is an example of the difficulties arising in the management of bilateral tumors of the Wilms type, with the main problem being the balance between tumor excision and kidney preservation in a child. In this case, neoadjuvant chemotherapy followed by nephron-sparing surgery was efficient, thereby allowing complete resection of large tumors while maintaining kidney function. This case highlights the feasibility of single-stage bilateral NSS in large, organ-displacing tumors, a less commonly reported approach. The absence of inferior vena cava invasion, suprarenal involvement, and the need for renal pelvic repair during NSS adds to the surgical complexities. Our findings contribute to the evolving discussion on optimizing renal preservation strategies in bilateral Wilms' tumor.

Funding Information

Not applicable.

Conflict of Interest Statement

The authors declare no conflicts of interest.

Ethics Statement

Informed consent was obtained from the patient. Our institution does not require ethical approval for the case reports.

Informed Consent

The parents signed an informed consent form allowing the use of clinical data, imaging, and anonymized information related to their child's diagnosis and treatment in diagnostics, scientific research, and publication. They also provided consent for anonymized images and details of this case report for educational and research purposes.

References

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