eng Science and Education Publishing American Journal of Medical Case Reports 2374-216X 2023-02-21 11 2 33 36 10.12691/ajmcr-11-2-7 AJMCR20231127 article Chiara Rosenbaum chiara.rosenbaum@beaumont.org 1 Jamila Asif 2 Amer Kadri 3 Rajiv John 3 Department of Dermatology, Beaumont Hospital-Trenton, MI Department of Internal Medicine, Beaumont Hospital-Dearborn, MI Department of Cardiology, Albert Einstein Medical Center, Philadelphia, Pennsylvania Congestive Hepatopathy (CH) is an important differential diagnosis when evaluating patients who present with right upper quadrant pain, hyperbilirubinemia, and jaundice. We describe a 54-year-old male with a chronic pericardial effusion who develops cholestatic jaundice and acute hepatic injury as a result of early cardiac tamponade. This case report demonstrates the challenges in diagnosing congestive hepatopathy and reviews the pathophysiology that leads to variable presentations of the condition. http://pubs.sciepub.com/ajmcr/11/2/7/ajmcr-11-2-7.pdf Congestive Hepatopathy Pericardial effusion Elevated liver enzymes Abdominal pain