eng Science and Education Publishing American Journal of Medical Case Reports 2374-216X 2023-02-05 11 2 23 27 10.12691/ajmcr-11-2-4 AJMCR20231124 article Lydia Leavitt Lleavi3@uic.edu 1 University of Illinois College of Medicine, Rockford, IL, United States Brain death is a difficult determination, often involving legal, ethical, and moral dilemmas for care teams and families. Determination of brain death in the neonate is particularly difficult due to ambiguous and inconsistent guidelines, which have generated controversies and debates regarding several components of the brain death examination in neonates. The treatment team of a term neonate who suffered a severe hypoxic-ischemic brain injury during birth encountered numerous uncertainties as they navigated the brain death determination guidelines. This was the first time a neonatal brain death determination was performed at this 52-bed level III neonatal intensive care unit. http://pubs.sciepub.com/ajmcr/11/2/4/ajmcr-11-2-4.pdf neonatology brain death hypoxic-ischemic encephalopathy